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2XK7

Structure of Nek2 bound to aminopyrazine compound 23

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 30E A 1280
ChainResidue
ACYS22
AASP93
ASER96
AASP159
AVAL35
ATYR70
AMET86
AGLU87
ATYR88
ACYS89
AGLU90
AGLY92

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1282
ChainResidue
AGLU110
AARG239

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1283
ChainResidue
AASN154
AHIS277
AHIS279
AHOH2107

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1284
ChainResidue
ASER261
AVAL262
AHOH2067
AHOH2093

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1285
ChainResidue
AARG235
AHOH2066

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL
ChainResidueDetails
AVAL137-LEU149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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