2XJB

Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with deoxyguanosine monophosphate and deoxyadenosine triphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000255	biological_process	allantoin metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046037	biological_process	GMP metabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1489

Chain	Residue
A	SER93
A	PRO96
A	THR97
A	GLU378
A	TYR434
A	GLY438
A	HOH2060
A	HOH2225
A	HOH2230

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE DTP A 1490

Chain	Residue
A	ARG144
A	ASP145
A	ASN154
A	PHE354
A	LYS362
A	GLN453
A	ARG456
A	TYR457
A	MG1495
A	MG1495
A	HOH2250
A	HOH2251
A	HOH2252
A	HOH2253
A	HOH2254
A	HOH2255
A	HOH2255
A	HOH2256
A	HOH2257
A	HOH2258

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE DGP A 1491

Chain	Residue
A	ASN52
A	MET53
A	ASP54
A	PHE157
A	ARG202
A	ASP206
A	HIS209
A	LYS215
A	THR249
A	ASN250
A	SER251
A	LYS292
A	MG1494
A	HOH2148
A	HOH2213
A	HOH2216
A	HOH2263

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1492

Chain	Residue
A	PHE283
A	ASP284
A	ILE286
A	GLN322
A	HIS323
A	GLY324
A	ILE325

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1493

Chain	Residue
A	ASP252
A	TYR253
A	LYS254
A	ASP289
A	GLY310

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1494

Chain	Residue
A	ASN52
A	ASP54
A	ASP351
A	DGP1491
A	HOH2213
A	HOH2216

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1495

Chain	Residue
A	DTP1490
A	DTP1490
A	HOH2255
A	HOH2255

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---