2XIG
The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT B 1149 |
| Chain | Residue |
| B | LEU23 |
| B | LYS24 |
| B | ASN25 |
| B | ARG29 |
| B | ARG66 |
| B | HOH2054 |
| D | ARG66 |
| D | ASN69 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1149 |
| Chain | Residue |
| A | ASP98 |
| A | GLU117 |
| A | HIS134 |
| A | HIS96 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1150 |
| Chain | Residue |
| B | HIS42 |
| B | GLU90 |
| B | HIS97 |
| B | HIS99 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1151 |
| Chain | Residue |
| C | HIS42 |
| C | GLU90 |
| C | HIS97 |
| C | HIS99 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1150 |
| Chain | Residue |
| A | HIS42 |
| A | GLU90 |
| A | HIS97 |
| A | HIS99 |
| A | GLU110 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1151 |
| Chain | Residue |
| B | HIS96 |
| B | ASP98 |
| B | GLU117 |
| B | HIS134 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1152 |
| Chain | Residue |
| C | CYS102 |
| C | CYS105 |
| C | CYS142 |
| C | CYS145 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1152 |
| Chain | Residue |
| B | CYS102 |
| B | CYS105 |
| B | CYS142 |
| B | CYS145 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1149 |
| Chain | Residue |
| D | CYS102 |
| D | CYS105 |
| D | CYS142 |
| D | CYS145 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1153 |
| Chain | Residue |
| C | HIS96 |
| C | ASP98 |
| C | GLU117 |
| C | HIS134 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1150 |
| Chain | Residue |
| D | HIS96 |
| D | ASP98 |
| D | GLU117 |
| D | HIS134 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1151 |
| Chain | Residue |
| D | HIS42 |
| D | GLU90 |
| D | HIS97 |
| D | HIS99 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1151 |
| Chain | Residue |
| A | CYS102 |
| A | CYS105 |
| A | CYS142 |
| A | CYS145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 276 |
| Details | Region: {"description":"DNA-binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
