2XGC

Crystal structure of a designed heterodimeric variant T-A(I)B of the tetracycline repressor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
B	0003677	molecular_function	DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046677	biological_process	response to antibiotic

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIeglTTrkLaqklgVEqPtLYwHVkNKralL

Chain	Residue	Details
B	GLY21-LEU52
A	GLY21-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
B	THR26-VAL45

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:8153629, ECO:0007744|PDB:2TRT

Chain	Residue	Details
B	HIS64
B	ASN82
B	HIS100

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