Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XE5

Molecular insights into clinically isolated OmpC mutants and their role in multi-drug resistance (OmpC26)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006811	biological_process	monoatomic ion transport
A	0009279	cellular_component	cell outer membrane
A	0015288	molecular_function	porin activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046930	cellular_component	pore complex
B	0006811	biological_process	monoatomic ion transport
B	0009279	cellular_component	cell outer membrane
B	0015288	molecular_function	porin activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046930	cellular_component	pore complex
C	0006811	biological_process	monoatomic ion transport
C	0009279	cellular_component	cell outer membrane
C	0015288	molecular_function	porin activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046930	cellular_component	pore complex
D	0006811	biological_process	monoatomic ion transport
D	0009279	cellular_component	cell outer membrane
D	0015288	molecular_function	porin activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046930	cellular_component	pore complex
E	0006811	biological_process	monoatomic ion transport
E	0009279	cellular_component	cell outer membrane
E	0015288	molecular_function	porin activity
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0046930	cellular_component	pore complex
F	0006811	biological_process	monoatomic ion transport
F	0009279	cellular_component	cell outer membrane
F	0015288	molecular_function	porin activity
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0046930	cellular_component	pore complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE C8E A 1344

Chain	Residue
A	TYR235
A	GLN254
A	LYS278
B	PHE23
C	D121346

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEX A 1345

Chain	Residue
A	D121346

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE D12 A 1346

Chain	Residue
A	TYR313
A	ASP333
A	HEX1345

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OCT A 1347

Chain	Residue
A	THR219
A	GLY220
C	TYR149
C	HEX1344

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1348

Chain	Residue
A	LYS16
A	TYR35
A	ARG37
A	SO41349
A	HOH2086
A	HOH2087

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1349

Chain	Residue
A	ARG37
A	ARG74
A	ARG124
A	SO41348

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEX A 1350

Chain	Residue
A	LEU317
B	ILE315

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OCT A 1351

Chain	Residue
A	TYR218

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE D10 B 1344

Chain	Residue
A	ALA232

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE D10 B 1345

Chain	Residue
E	TYR90
E	ASP175

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE D10 B 1346

Chain	Residue
E	VAL295
F	ILE315

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE D10 B 1347

Chain	Residue
C	VAL85
C	GLY86

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE D10 B 1348

Chain	Residue
A	TYR274
A	LYS278
A	HOH2064
B	VAL335

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE D10 B 1349

Chain	Residue
B	LYS293

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASZ B 1350

Chain	Residue
B	LYS16
B	TYR35
B	ARG37
B	ARG74
B	GLN123
B	ARG124
B	HOH2040

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE C8E B 1351

Chain	Residue
B	VAL297

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OES B 1352

Chain	Residue
B	TYR149
B	ASP175
B	GLY176

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEX B 1353

Chain	Residue
B	LYS252
B	GLN254
F	ASN281

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HP6 B 1354

Chain	Residue
B	LEU339

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OCT B 1358

Chain	Residue
B	VAL295
B	LEU317

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEX C 1344

Chain	Residue
A	OCT1347
C	TYR131

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEX C 1345

Chain	Residue
C	GLN237

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE D12 C 1346

Chain	Residue
A	GLY191
A	GLY220
A	GLY221
A	C8E1344
C	TYR131
C	TYR149

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1348

Chain	Residue
C	LYS16
C	TYR35
C	ARG37
C	HOH2003

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEX C 1350

Chain	Residue
C	TYR183

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE C8E D 1344

Chain	Residue
D	TYR90
D	TYR149
D	GLN150
D	GLY151
D	GLY176
D	VAL177

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OES D 1345

Chain	Residue
D	LEU80
D	LYS81
D	PHE82
D	VAL85
D	TYR131
D	PHE145
E	ILE190

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OCT D 1347

Chain	Residue
D	TYR131
D	TYR149
E	GLY220
E	GLY221

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1348

Chain	Residue
D	GLN123
D	ARG124
D	HOH2070

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEX E 1344

Chain	Residue
E	LYS278
E	LYS280
E	ASP290

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE D12 E 1345

Chain	Residue
E	ALA233
F	PHE23

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE D12 E 1346

Chain	Residue
E	LYS223
E	TYR224
E	LEU231
E	VAL259

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE D12 E 1347

Chain	Residue
E	ILE315

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OCT E 1348

Chain	Residue
E	LEU337

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEX F 1344

Chain	Residue
B	ASN281
F	GLN237
F	TYR239

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HP6 F 1345

Chain	Residue
F	LEU317

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OCT F 1347

Chain	Residue
E	TYR274
E	GLN276
F	VAL335

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1348

Chain	Residue
F	ARG37
F	ARG74
F	GLN123
F	ARG124
F	SO41349

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1349

Chain	Residue
F	LYS16
F	TYR35
F	ARG37
F	SO41348
F	HOH2022

Functional Information from PROSITE/UniProt

site_id	PS00576
Number of Residues	17
Details	GRAM_NEG_PORIN General diffusion Gram-negative porins signature. VdvGatYyFnKnmSTYV

Chain	Residue	Details
A	VAL295-VAL311

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)