2XE1

Molecular insights into clinically isolated OmpC mutants and their role in multi-drug resistance

Replaces:  2IXX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006811	biological_process	monoatomic ion transport
A	0009279	cellular_component	cell outer membrane
A	0015288	molecular_function	porin activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046930	cellular_component	pore complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEX A 1355

Chain	Residue
A	VAL346

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE D10 A 1356

Chain	Residue
A	PHE23
A	TYR90
A	TYR149
A	LEU348

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE D10 A 1357

Chain	Residue
A	TYR269
A	VAL279
A	VAL306

---

Functional Information from PROSITE/UniProt

site_id	PS00576
Number of Residues	17
Details	GRAM_NEG_PORIN General diffusion Gram-negative porins signature. VdvGatYyFnKnmSTYV

Chain	Residue	Details
A	VAL306-VAL322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	181
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"22053181","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"22053181","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	81
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22053181","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22053181","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27723824","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---