2XDO
Structure of the Tetracycline degrading Monooxygenase TetX2 from Bacteroides thetaiotaomicron
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071949 | molecular_function | FAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071949 | molecular_function | FAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0071949 | molecular_function | FAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0046677 | biological_process | response to antibiotic |
| D | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 389 |
| Chain | Residue |
| A | GLY23 |
| A | ASP61 |
| A | ARG117 |
| A | ARG121 |
| A | ARG137 |
| A | LYS138 |
| A | LEU139 |
| A | ALA167 |
| A | ASN168 |
| A | GLY169 |
| A | GLN192 |
| A | GLY25 |
| A | GLY310 |
| A | ASP311 |
| A | PRO318 |
| A | GLY323 |
| A | VAL324 |
| A | HOH2021 |
| A | HOH2031 |
| A | HOH2066 |
| A | HOH2067 |
| A | HOH2156 |
| A | PRO26 |
| A | HOH2173 |
| A | HOH2174 |
| A | HOH2175 |
| A | HOH2176 |
| A | VAL27 |
| A | TYR45 |
| A | GLU46 |
| A | ARG47 |
| A | THR59 |
| A | LEU60 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 391 |
| Chain | Residue |
| A | ARG54 |
| A | HOH2178 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 392 |
| Chain | Residue |
| A | ARG137 |
| A | LYS156 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 393 |
| Chain | Residue |
| A | ARG47 |
| A | MET171 |
| site_id | AC5 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD B 389 |
| Chain | Residue |
| B | GLY23 |
| B | GLY25 |
| B | PRO26 |
| B | VAL27 |
| B | TYR45 |
| B | GLU46 |
| B | ARG47 |
| B | LEU60 |
| B | ASP61 |
| B | ARG117 |
| B | ARG121 |
| B | ARG137 |
| B | LYS138 |
| B | LEU139 |
| B | ALA167 |
| B | ASN168 |
| B | GLY169 |
| B | GLN192 |
| B | GLY310 |
| B | ASP311 |
| B | PRO318 |
| B | GLY323 |
| B | VAL324 |
| B | HOH2022 |
| B | HOH2031 |
| B | HOH2052 |
| B | HOH2062 |
| B | HOH2063 |
| B | HOH2088 |
| B | HOH2150 |
| B | HOH2158 |
| B | HOH2169 |
| B | HOH2170 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 391 |
| Chain | Residue |
| B | ARG54 |
| B | HOH2171 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 392 |
| Chain | Residue |
| B | ARG137 |
| B | LYS156 |
| B | HOH2172 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 393 |
| Chain | Residue |
| B | ARG47 |
| B | MET171 |
| B | HOH2089 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 394 |
| Chain | Residue |
| B | LEU287 |
| B | ALA288 |
| B | ARG290 |
| B | HOH2174 |
| site_id | BC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD C 389 |
| Chain | Residue |
| C | LEU139 |
| C | ALA167 |
| C | ASN168 |
| C | GLY169 |
| C | GLY310 |
| C | ASP311 |
| C | PRO318 |
| C | GLY323 |
| C | VAL324 |
| C | HOH2008 |
| C | HOH2043 |
| C | HOH2044 |
| C | HOH2090 |
| C | HOH2093 |
| C | HOH2102 |
| C | HOH2111 |
| C | HOH2113 |
| C | GLY23 |
| C | GLY24 |
| C | GLY25 |
| C | PRO26 |
| C | VAL27 |
| C | TYR45 |
| C | GLU46 |
| C | ARG47 |
| C | ASP48 |
| C | LEU60 |
| C | ASP61 |
| C | ARG117 |
| C | ARG121 |
| C | ARG137 |
| C | LYS138 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 391 |
| Chain | Residue |
| C | ALA53 |
| C | ARG54 |
| C | HOH2112 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 392 |
| Chain | Residue |
| C | ARG137 |
| C | LYS156 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 393 |
| Chain | Residue |
| C | ARG47 |
| C | MET171 |
| site_id | BC5 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD D 389 |
| Chain | Residue |
| D | GLY23 |
| D | GLY24 |
| D | GLY25 |
| D | PRO26 |
| D | VAL27 |
| D | TYR45 |
| D | GLU46 |
| D | ARG47 |
| D | ASP48 |
| D | LEU60 |
| D | ARG117 |
| D | ARG121 |
| D | ARG137 |
| D | LYS138 |
| D | LEU139 |
| D | ALA167 |
| D | ASN168 |
| D | GLY169 |
| D | GLY310 |
| D | ASP311 |
| D | PRO318 |
| D | GLY323 |
| D | VAL324 |
| D | HOH2011 |
| D | HOH2021 |
| D | HOH2033 |
| D | HOH2040 |
| D | HOH2053 |
| D | HOH2060 |
| D | HOH2093 |
| D | HOH2099 |
| D | HOH2105 |
| D | HOH2106 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 391 |
| Chain | Residue |
| A | ARG54 |
| D | ALA53 |
| D | ARG54 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 392 |
| Chain | Residue |
| D | ARG137 |
| D | LYS156 |
| D | HOH2046 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 393 |
| Chain | Residue |
| D | ARG47 |
| D | MET171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV |
| Chain | Residue | Details |
| A | PRO26 | |
| C | TYR45 | |
| C | LEU139 | |
| C | GLY321 | |
| D | PRO26 | |
| D | TYR45 | |
| D | LEU139 | |
| D | GLY321 | |
| A | TYR45 | |
| A | LEU139 | |
| A | GLY321 | |
| B | PRO26 | |
| B | TYR45 | |
| B | LEU139 | |
| B | GLY321 | |
| C | PRO26 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000305|PubMed:21402075 |
| Chain | Residue | Details |
| A | ARG54 | |
| B | ARG54 | |
| C | ARG54 | |
| D | ARG54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0007744|PDB:3V3O |
| Chain | Residue | Details |
| A | ASP61 | |
| B | ASP61 | |
| C | ASP61 | |
| D | ASP61 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV |
| Chain | Residue | Details |
| A | ARG117 | |
| A | ASP311 | |
| B | ARG117 | |
| B | ASP311 | |
| C | ARG117 | |
| C | ASP311 | |
| D | ARG117 | |
| D | ASP311 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:4A99 |
| Chain | Residue | Details |
| A | GLN192 | |
| B | GLN192 | |
| C | GLN192 | |
| D | GLN192 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99 |
| Chain | Residue | Details |
| A | ARG213 | |
| B | ARG213 | |
| C | ARG213 | |
| D | ARG213 |
