2XCU

Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016740	molecular_function	transferase activity
A	0043842	molecular_function	Kdo transferase activity
B	0005886	cellular_component	plasma membrane
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016740	molecular_function	transferase activity
B	0043842	molecular_function	Kdo transferase activity
C	0005886	cellular_component	plasma membrane
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0009244	biological_process	lipopolysaccharide core region biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016740	molecular_function	transferase activity
C	0043842	molecular_function	Kdo transferase activity
D	0005886	cellular_component	plasma membrane
D	0009103	biological_process	lipopolysaccharide biosynthetic process
D	0009244	biological_process	lipopolysaccharide core region biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016740	molecular_function	transferase activity
D	0043842	molecular_function	Kdo transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C5P A 400

Chain	Residue
A	SER182
A	ASN273
A	GLU276
A	HOH2033
A	HOH2034
A	VAL210
A	PRO211
A	ARG212
A	PHE247
A	GLY248
A	ILE249
A	LEU250
A	HIS272

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1PE A 1353

Chain	Residue
A	PHE3
A	VAL5
A	ARG8
A	PHE53
A	PRO55
A	CIT1356
C	ARG99
C	GLU100
C	PHE101

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1PE A 1354

Chain	Residue
A	ARG99
A	GLU100
A	PHE101
C	PHE3
C	VAL5
C	ARG8
C	PHE53
C	PRO55
C	CIT1353

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CIT A 1355

Chain	Residue
A	ILE183
A	HIS184
A	THR185
A	ARG212
A	HIS213
A	ASN216
A	PHE220
C	HIS184
C	THR185
C	HIS213
C	ASN216

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CIT A 1356

Chain	Residue
A	GLN2
A	PHE3
A	GLU4
A	VAL5
A	LEU6
A	1PE1353
C	ARG99
C	LYS121
C	SER123
C	ILE125

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE C5P B 400

Chain	Residue
B	SER182
B	VAL210
B	PRO211
B	ARG212
B	PHE247
B	GLY248
B	ILE249
B	LEU250
B	LYS251
B	HIS272
B	ASN273
B	GLU276
B	HOH2020
B	HOH2028
B	HOH2029

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE B 1353

Chain	Residue
B	ARG99
B	GLU100
B	PHE101
B	TRP102
D	PHE3
D	VAL5
D	ARG8
D	PHE53
D	PRO55
D	CIT1354

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT B 1354

Chain	Residue
B	GLN2
B	PHE3
B	GLU4
B	VAL5
B	LEU6
D	ARG99
D	LYS121
D	SER123
D	1PE1353

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME B 1355

Chain	Residue
B	PHE9
B	ARG84

---

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE C5P C 400

Chain	Residue
C	ASN273
C	GLU276
C	HOH2025
C	HOH2026
C	HOH2027
C	SER182
C	VAL210
C	PRO211
C	ARG212
C	ILE214
C	PHE247
C	GLY248
C	ILE249
C	LEU250
C	LYS251
C	HIS272

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CIT C 1353

Chain	Residue
A	ARG99
A	LYS121
A	SER123
A	ILE125
A	1PE1354
A	HOH2017
C	GLN2
C	PHE3
C	GLU4
C	VAL5
C	LEU6

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME C 1354

Chain	Residue
C	PHE9
C	PHE80

---

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE C5P D 400

Chain	Residue
D	SER182
D	VAL210
D	PRO211
D	ARG212
D	PHE247
D	GLY248
D	ILE249
D	LEU250
D	LYS251
D	HIS272
D	ASN273
D	GLU276
D	HOH2024
D	HOH2025
D	HOH2026

---

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE D 1353

Chain	Residue
B	PHE3
B	VAL5
B	ARG8
B	PHE53
B	PRO55
B	CIT1354
D	ARG99
D	GLU100
D	PHE101
D	TRP102

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT D 1354

Chain	Residue
B	LYS121
B	SER123
B	ILE125
B	1PE1353
D	GLN2
D	PHE3
D	GLU4
D	VAL5
D	LEU6

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME D 1355

Chain	Residue
D	PHE10
D	PHE80
D	ARG84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:22474366

Chain	Residue	Details
A	GLU31
B	GLU31
C	GLU31
D	GLU31

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:22474366, ECO:0007744|PDB:2XCU

Chain	Residue	Details
A	PRO211
D	PRO211
D	PHE247
D	ASN273
A	PHE247
A	ASN273
B	PRO211
B	PHE247
B	ASN273
C	PRO211
C	PHE247
C	ASN273

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	GLU98
A	LYS162
B	GLU98
B	LYS162
C	GLU98
C	LYS162
D	GLU98
D	LYS162

---