2XCU
Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0043842 | molecular_function | Kdo transferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0043842 | molecular_function | Kdo transferase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0043842 | molecular_function | Kdo transferase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| D | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0043842 | molecular_function | Kdo transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE C5P A 400 |
| Chain | Residue |
| A | SER182 |
| A | ASN273 |
| A | GLU276 |
| A | HOH2033 |
| A | HOH2034 |
| A | VAL210 |
| A | PRO211 |
| A | ARG212 |
| A | PHE247 |
| A | GLY248 |
| A | ILE249 |
| A | LEU250 |
| A | HIS272 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1353 |
| Chain | Residue |
| A | PHE3 |
| A | VAL5 |
| A | ARG8 |
| A | PHE53 |
| A | PRO55 |
| A | CIT1356 |
| C | ARG99 |
| C | GLU100 |
| C | PHE101 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1354 |
| Chain | Residue |
| A | ARG99 |
| A | GLU100 |
| A | PHE101 |
| C | PHE3 |
| C | VAL5 |
| C | ARG8 |
| C | PHE53 |
| C | PRO55 |
| C | CIT1353 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT A 1355 |
| Chain | Residue |
| A | ILE183 |
| A | HIS184 |
| A | THR185 |
| A | ARG212 |
| A | HIS213 |
| A | ASN216 |
| A | PHE220 |
| C | HIS184 |
| C | THR185 |
| C | HIS213 |
| C | ASN216 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT A 1356 |
| Chain | Residue |
| A | GLN2 |
| A | PHE3 |
| A | GLU4 |
| A | VAL5 |
| A | LEU6 |
| A | 1PE1353 |
| C | ARG99 |
| C | LYS121 |
| C | SER123 |
| C | ILE125 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE C5P B 400 |
| Chain | Residue |
| B | SER182 |
| B | VAL210 |
| B | PRO211 |
| B | ARG212 |
| B | PHE247 |
| B | GLY248 |
| B | ILE249 |
| B | LEU250 |
| B | LYS251 |
| B | HIS272 |
| B | ASN273 |
| B | GLU276 |
| B | HOH2020 |
| B | HOH2028 |
| B | HOH2029 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PE B 1353 |
| Chain | Residue |
| B | ARG99 |
| B | GLU100 |
| B | PHE101 |
| B | TRP102 |
| D | PHE3 |
| D | VAL5 |
| D | ARG8 |
| D | PHE53 |
| D | PRO55 |
| D | CIT1354 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT B 1354 |
| Chain | Residue |
| B | GLN2 |
| B | PHE3 |
| B | GLU4 |
| B | VAL5 |
| B | LEU6 |
| D | ARG99 |
| D | LYS121 |
| D | SER123 |
| D | 1PE1353 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME B 1355 |
| Chain | Residue |
| B | PHE9 |
| B | ARG84 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE C5P C 400 |
| Chain | Residue |
| C | ASN273 |
| C | GLU276 |
| C | HOH2025 |
| C | HOH2026 |
| C | HOH2027 |
| C | SER182 |
| C | VAL210 |
| C | PRO211 |
| C | ARG212 |
| C | ILE214 |
| C | PHE247 |
| C | GLY248 |
| C | ILE249 |
| C | LEU250 |
| C | LYS251 |
| C | HIS272 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT C 1353 |
| Chain | Residue |
| A | ARG99 |
| A | LYS121 |
| A | SER123 |
| A | ILE125 |
| A | 1PE1354 |
| A | HOH2017 |
| C | GLN2 |
| C | PHE3 |
| C | GLU4 |
| C | VAL5 |
| C | LEU6 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME C 1354 |
| Chain | Residue |
| C | PHE9 |
| C | PHE80 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE C5P D 400 |
| Chain | Residue |
| D | SER182 |
| D | VAL210 |
| D | PRO211 |
| D | ARG212 |
| D | PHE247 |
| D | GLY248 |
| D | ILE249 |
| D | LEU250 |
| D | LYS251 |
| D | HIS272 |
| D | ASN273 |
| D | GLU276 |
| D | HOH2024 |
| D | HOH2025 |
| D | HOH2026 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PE D 1353 |
| Chain | Residue |
| B | PHE3 |
| B | VAL5 |
| B | ARG8 |
| B | PHE53 |
| B | PRO55 |
| B | CIT1354 |
| D | ARG99 |
| D | GLU100 |
| D | PHE101 |
| D | TRP102 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT D 1354 |
| Chain | Residue |
| B | LYS121 |
| B | SER123 |
| B | ILE125 |
| B | 1PE1353 |
| D | GLN2 |
| D | PHE3 |
| D | GLU4 |
| D | VAL5 |
| D | LEU6 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME D 1355 |
| Chain | Residue |
| D | PHE10 |
| D | PHE80 |
| D | ARG84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22474366","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22474366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
