2XCN
Crystal structure of HCV NS3 protease with a boronate inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | transformation of host cell by virus |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097264 | biological_process | self proteolysis |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019062 | biological_process | virion attachment to host cell |
| B | 0019087 | biological_process | transformation of host cell by virus |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0044423 | cellular_component | virion component |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097264 | biological_process | self proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE C8D A 1181 |
| Chain | Residue |
| A | HIS57 |
| A | ASP168 |
| A | ARG123 |
| A | LEU135 |
| A | GLY137 |
| A | SER139 |
| A | PHE154 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE C8D B 1181 |
| Chain | Residue |
| B | HIS57 |
| B | ASP81 |
| B | ARG123 |
| B | SER139 |
| B | ARG155 |
| B | ALA156 |
| B | ALA157 |
| B | ARG161 |
| B | ASP168 |
| B | HOH2020 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1041 |
| Chain | Residue |
| A | THR4 |
| C | LEU31 |
| C | GLY33 |
| C | HOH2002 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1182 |
| Chain | Residue |
| A | ALA5 |
| A | ALA111 |
| A | HOH2014 |
| B | HOH2013 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1183 |
| Chain | Residue |
| A | CYS97 |
| A | THR98 |
| A | CYS99 |
| A | CYS145 |
| A | HOH2024 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1182 |
| Chain | Residue |
| B | CYS97 |
| B | THR98 |
| B | CYS99 |
| B | CYS145 |
| B | HOH2021 |
