2XCI
Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0043842 | molecular_function | Kdo transferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0043842 | molecular_function | Kdo transferase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016740 | molecular_function | transferase activity |
| C | 0043842 | molecular_function | Kdo transferase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| D | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016740 | molecular_function | transferase activity |
| D | 0043842 | molecular_function | Kdo transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 D 1353 |
| Chain | Residue |
| B | PHE3 |
| B | VAL5 |
| B | ARG8 |
| B | PHE53 |
| B | GOL1353 |
| D | ARG99 |
| D | GLU100 |
| D | PHE101 |
| D | TRP102 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1353 |
| Chain | Residue |
| A | ARG8 |
| C | PHE101 |
| C | TRP102 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 D 1354 |
| Chain | Residue |
| B | PHE53 |
| B | GLU100 |
| B | PHE101 |
| D | PHE3 |
| D | VAL5 |
| D | ARG8 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1354 |
| Chain | Residue |
| A | ARG99 |
| A | GLU100 |
| A | PHE101 |
| A | TRP102 |
| C | PHE3 |
| C | VAL5 |
| C | ARG8 |
| C | PHE53 |
| C | PRO55 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1355 |
| Chain | Residue |
| B | ILE125 |
| D | GLU4 |
| D | VAL5 |
| D | LEU6 |
| D | LYS7 |
| D | HOH2001 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1355 |
| Chain | Residue |
| A | GLN2 |
| A | PHE3 |
| A | GLU4 |
| A | GOL1356 |
| C | ARG99 |
| C | LYS121 |
| C | SER123 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1356 |
| Chain | Residue |
| A | GLU4 |
| A | VAL5 |
| A | LEU6 |
| A | LYS7 |
| A | GOL1355 |
| C | LEU124 |
| C | ILE125 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1353 |
| Chain | Residue |
| A | LYS121 |
| A | SER123 |
| C | MET1 |
| C | GLN2 |
| C | PHE3 |
| C | GLU4 |
| C | GOL1354 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 1354 |
| Chain | Residue |
| A | SER123 |
| A | LEU124 |
| A | ILE125 |
| C | GLU4 |
| C | VAL5 |
| C | LEU6 |
| C | LYS7 |
| C | GOL1353 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1357 |
| Chain | Residue |
| A | HIS184 |
| A | THR185 |
| A | HIS213 |
| A | ASN216 |
| A | HOH2039 |
| C | HIS213 |
| C | ASN216 |
| C | BME1355 |
| C | BME1356 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1353 |
| Chain | Residue |
| B | GLU4 |
| B | VAL5 |
| B | LEU6 |
| B | LYS7 |
| B | HOH2004 |
| D | ILE125 |
| D | PG41353 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1356 |
| Chain | Residue |
| B | HIS184 |
| B | THR185 |
| B | ASN216 |
| D | HIS184 |
| D | HIS213 |
| D | ASN216 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME C 1355 |
| Chain | Residue |
| A | GOL1357 |
| C | HIS213 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BME C 1356 |
| Chain | Residue |
| A | GOL1357 |
| C | ILE183 |
| C | HIS184 |
| C | THR185 |
| C | PRO211 |
| C | ARG212 |
| C | HIS213 |
| C | ASN216 |
| C | PHE220 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 1357 |
| Chain | Residue |
| D | PHE9 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI D 1358 |
| Chain | Residue |
| D | HIS213 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI B 1354 |
| Chain | Residue |
| B | HIS213 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A 1358 |
| Chain | Residue |
| A | HIS213 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI C 1357 |
| Chain | Residue |
| C | HIS213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:22474366 |
| Chain | Residue | Details |
| A | GLU31 | |
| B | GLU31 | |
| C | GLU31 | |
| D | GLU31 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22474366, ECO:0007744|PDB:2XCU |
| Chain | Residue | Details |
| A | PRO211 | |
| D | PRO211 | |
| D | PHE247 | |
| D | ASN273 | |
| A | PHE247 | |
| A | ASN273 | |
| B | PRO211 | |
| B | PHE247 | |
| B | ASN273 | |
| C | PRO211 | |
| C | PHE247 | |
| C | ASN273 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | GLU98 | |
| A | LYS162 | |
| B | GLU98 | |
| B | LYS162 | |
| C | GLU98 | |
| C | LYS162 | |
| D | GLU98 | |
| D | LYS162 |
