2XC3
X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051701 | biological_process | biological process involved in interaction with host |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM A 1433 |
| Chain | Residue |
| A | LEU117 |
| A | PRO312 |
| A | PHE316 |
| A | ARG318 |
| A | GLY368 |
| A | PHE369 |
| A | GLY371 |
| A | ALA374 |
| A | HIS375 |
| A | CYS377 |
| A | ILE378 |
| A | HIS124 |
| A | GLY379 |
| A | HOH2401 |
| A | HOH2580 |
| A | HOH2581 |
| A | HOH2582 |
| A | ARG128 |
| A | MET264 |
| A | ALA268 |
| A | GLY269 |
| A | THR272 |
| A | THR273 |
| A | SER276 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE RT8 A 1434 |
| Chain | Residue |
| A | ILE97 |
| A | PHE100 |
| A | ASP108 |
| A | GLN112 |
| A | VAL115 |
| A | LEU117 |
| A | THR201 |
| A | LYS214 |
| A | PHE260 |
| A | VAL263 |
| A | VAL267 |
| A | TRP414 |
| A | HOH2205 |
| A | HOH2339 |
| A | HOH2583 |
| A | HOH2584 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19846552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20545858","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X5L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XN8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
