2XAR

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from A. thaliana in complex with IP6.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0010264	biological_process	myo-inositol hexakisphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030643	biological_process	intracellular phosphate ion homeostasis
A	0032942	molecular_function	inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
A	0032958	biological_process	inositol phosphate biosynthetic process
A	0035299	molecular_function	inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
A	0042742	biological_process	defense response to bacterium
A	0046872	molecular_function	metal ion binding
A	0048527	biological_process	lateral root development
A	0050832	biological_process	defense response to fungus
A	0051607	biological_process	defense response to virus
A	0055062	biological_process	phosphate ion homeostasis
A	0102731	molecular_function	inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0010264	biological_process	myo-inositol hexakisphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030643	biological_process	intracellular phosphate ion homeostasis
B	0032942	molecular_function	inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
B	0032958	biological_process	inositol phosphate biosynthetic process
B	0035299	molecular_function	inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
B	0042742	biological_process	defense response to bacterium
B	0046872	molecular_function	metal ion binding
B	0048527	biological_process	lateral root development
B	0050832	biological_process	defense response to fungus
B	0051607	biological_process	defense response to virus
B	0055062	biological_process	phosphate ion homeostasis
B	0102731	molecular_function	inositol-1,3,4,6-tetrakisphosphate 2-kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE IHP A 500

Chain	Residue
A	GLY19
A	ASN238
A	ASP368
A	LYS411
A	ARG415
A	TYR419
A	GLY20
A	ALA21
A	ARG45
A	ARG130
A	LYS168
A	LYS170
A	HIS196
A	LYS200

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 700

Chain	Residue
A	HIS320
A	CYS330
A	CYS333
A	HIS346

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE IHP B 500

Chain	Residue
B	GLY19
B	GLY20
B	ALA21
B	ARG45
B	ARG130
B	LYS168
B	LYS170
B	LYS200
B	ASN238
B	ASP368
B	LYS411
B	ARG415
B	TYR419

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 700

Chain	Residue
B	HIS320
B	CYS330
B	CYS333
B	HIS346

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"EXKPK motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362712","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22684075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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