2X9D

Tet repressor (class D) in complex with iso-7-chlortetracycline

Replaces:  1DU7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ITC A 1209

Chain	Residue
A	HIS64
A	ILE134
A	SER138
A	HIS139
A	LEU170
A	LEU174
A	SER67
A	ASN82
A	PHE86
A	HIS100
A	ARG104
A	PRO105
A	VAL113
A	GLN116

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1210

Chain	Residue
A	LEU4
A	GLN76
A	ARG80

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1211

Chain	Residue
A	SER2
A	ARG3
A	SER74

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1212

Chain	Residue
A	ASN5
A	GLU7

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1213

Chain	Residue
A	THR40
A	LEU187
A	LEU190
A	GLU191

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	19
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8153629","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2TRT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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