2X8G
Oxidized thioredoxin glutathione reductase from Schistosoma mansoni
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0046872 | molecular_function | metal ion binding |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD A 1594 |
Chain | Residue |
A | ILE113 |
A | CYS154 |
A | VAL157 |
A | GLY158 |
A | CYS159 |
A | LYS162 |
A | ALA226 |
A | GLY228 |
A | ALA256 |
A | THR257 |
A | GLY258 |
A | GLY114 |
A | TYR296 |
A | VAL297 |
A | ARG393 |
A | VAL400 |
A | GLY432 |
A | ASP433 |
A | GLN440 |
A | LEU441 |
A | THR442 |
A | PRO443 |
A | GLY116 |
A | HIS571 |
A | PRO572 |
A | HOH2079 |
A | HOH2160 |
A | HOH2250 |
A | HOH2251 |
A | HOH2252 |
A | HOH2253 |
A | HOH2254 |
A | SER117 |
A | GLY118 |
A | ASP137 |
A | TYR138 |
A | GLY152 |
A | THR153 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEG A 1595 |
Chain | Residue |
A | ASP84 |
A | GLN86 |
A | THR87 |
A | GLU199 |
A | GLN202 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PEG A 1596 |
Chain | Residue |
A | ASP488 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 1597 |
Chain | Residue |
A | GLU462 |
A | LEU463 |
A | THR464 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PEG A 1598 |
Chain | Residue |
A | LYS13 |
A | ASP420 |
A | TYR429 |
A | LEU452 |
A | ARG455 |
A | LEU456 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 1599 |
Chain | Residue |
A | TYR335 |
A | TRP510 |
A | PRO542 |
A | HOH2045 |
A | HOH2185 |
A | HOH2255 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 1600 |
Chain | Residue |
A | TYR138 |
A | ASN225 |
A | LYS227 |
A | THR239 |
A | ASP240 |
A | LYS241 |
A | GLN243 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PG4 A 1601 |
Chain | Residue |
A | SER318 |
A | LEU320 |
A | GLN326 |
A | ALA329 |
A | GLU330 |
A | GLY333 |
A | ASP334 |
A | GLU337 |
A | PHE343 |
A | LYS345 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
Chain | Residue | Details |
A | GLY151-PRO161 |
site_id | PS00194 |
Number of Residues | 19 |
Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
Chain | Residue | Details |
A | VAL20-LEU38 |
site_id | PS00195 |
Number of Residues | 17 |
Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
Chain | Residue | Details |
A | LEU22-LEU38 |