2X8C
Thioredoxin glutathione reductase from Schistosoma mansoni with the reduced C-terminal end
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD A 1599 |
| Chain | Residue |
| A | GLY114 |
| A | THR153 |
| A | CYS154 |
| A | VAL157 |
| A | GLY158 |
| A | CYS159 |
| A | LYS162 |
| A | ALA226 |
| A | GLY228 |
| A | ALA256 |
| A | THR257 |
| A | GLY115 |
| A | GLY258 |
| A | TYR296 |
| A | ARG393 |
| A | VAL400 |
| A | GLY432 |
| A | ASP433 |
| A | GLN440 |
| A | LEU441 |
| A | THR442 |
| A | PRO443 |
| A | GLY116 |
| B | HIS571 |
| A | SER117 |
| A | GLY118 |
| A | LEU136 |
| A | ASP137 |
| A | TYR138 |
| A | GLY152 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 1595 |
| Chain | Residue |
| A | LEU320 |
| A | GLN326 |
| A | GLY333 |
| A | ASP334 |
| A | LYS345 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 1596 |
| Chain | Residue |
| A | SER172 |
| A | HIS173 |
| A | GLU176 |
| A | ALA306 |
| A | SER307 |
| A | TYR335 |
| A | HIS339 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 1597 |
| Chain | Residue |
| A | ASP488 |
| A | GLU491 |
| A | LYS492 |
| site_id | AC5 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD B 1599 |
| Chain | Residue |
| A | HIS571 |
| B | ILE113 |
| B | GLY114 |
| B | GLY115 |
| B | GLY116 |
| B | SER117 |
| B | GLY118 |
| B | LEU136 |
| B | ASP137 |
| B | TYR138 |
| B | VAL139 |
| B | GLY152 |
| B | THR153 |
| B | CYS154 |
| B | VAL157 |
| B | GLY158 |
| B | CYS159 |
| B | LYS162 |
| B | ALA226 |
| B | GLY228 |
| B | ALA256 |
| B | THR257 |
| B | GLY258 |
| B | TYR296 |
| B | ARG393 |
| B | VAL400 |
| B | GLY432 |
| B | ASP433 |
| B | GLN440 |
| B | LEU441 |
| B | THR442 |
| B | PRO443 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE B 1600 |
| Chain | Residue |
| B | LEU320 |
| B | GLN326 |
| B | ASP334 |
| B | GLU337 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY151-PRO161 |
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
| Chain | Residue | Details |
| A | VAL20-LEU38 |
| site_id | PS00195 |
| Number of Residues | 17 |
| Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
| Chain | Residue | Details |
| A | LEU22-LEU38 |
