2X62
CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II Y81F IN COMPLEX WITH CMP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1260 |
| Chain | Residue |
| B | LYS63 |
| B | ASP114 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1260 |
| Chain | Residue |
| A | ASP26 |
| A | VAL27 |
| A | LYS44 |
| A | CYS45 |
| A | LYS46 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE CH A 1261 |
| Chain | Residue |
| A | GLY10 |
| A | CYS30 |
| A | ASN31 |
| A | THR131 |
| A | SER132 |
| A | GLY133 |
| A | GLY152 |
| A | ILE153 |
| A | ASP154 |
| A | PHE155 |
| A | TYR156 |
| A | SER161 |
| A | TYR162 |
| A | HOH2075 |
| A | HOH2114 |
| A | HOH2115 |
| A | GLY8 |
| A | ASN9 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CH B 1261 |
| Chain | Residue |
| B | GLY8 |
| B | ASN9 |
| B | ASN31 |
| B | THR131 |
| B | SER132 |
| B | GLY133 |
| B | GLY152 |
| B | ILE153 |
| B | ASP154 |
| B | PHE155 |
| B | TYR156 |
| B | SER161 |
| B | TYR162 |
| B | HOH2004 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 840 |
| Chain | Residue | Details |
| A | ARG129 | electrostatic stabiliser |
| A | TYR156 | electrostatic stabiliser |
| A | TYR162 | electrostatic stabiliser |
| A | HIS188 | activator, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 840 |
| Chain | Residue | Details |
| B | ARG129 | electrostatic stabiliser |
| B | TYR156 | electrostatic stabiliser |
| B | TYR162 | electrostatic stabiliser |
| B | HIS188 | activator, proton acceptor, proton donor |
