2X4Y
Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2206 |
| Chain | Residue |
| A | ARG1110 |
| A | LEU1125 |
| A | HOH2148 |
| A | HOH2149 |
| A | HOH2150 |
| B | ARG26 |
| O | ARG1110 |
| O | LEU1125 |
| P | ARG26 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2204 |
| Chain | Residue |
| G | TYR1099 |
| G | ASP1149 |
| G | ASN1150 |
| G | SER1187 |
| G | HOH2114 |
| G | HOH2140 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2207 |
| Chain | Residue |
| A | TYR1099 |
| A | ASP1149 |
| A | ASN1150 |
| A | SER1187 |
| A | HOH2117 |
| A | HOH2152 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2208 |
| Chain | Residue |
| A | LYS1092 |
| A | CYS1093 |
| A | ARG1094 |
| A | LYS1161 |
| A | HOH2153 |
| A | HOH2154 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2205 |
| Chain | Residue |
| C | TYR1099 |
| C | ASP1149 |
| C | ASN1150 |
| C | SER1187 |
| C | HOH2109 |
| C | HOH2110 |
| C | HOH2111 |
| C | HOH2113 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2206 |
| Chain | Residue |
| E | ARG1110 |
| E | LEU1125 |
| E | HOH2163 |
| E | HOH2164 |
| E | HOH2165 |
| E | HOH2166 |
| F | ARG26 |
| I | ARG1110 |
| I | LEU1125 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1041 |
| Chain | Residue |
| C | HIS1115 |
| C | HIS1116 |
| C | ARG1180 |
| C | LYS1181 |
| C | ILE1184 |
| D | HIS39 |
| D | ARG40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 664 |
| Details | Domain: {"description":"PWWP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00162","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15684425","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
