2X4Y
Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2206 |
| Chain | Residue |
| A | ARG1110 |
| A | LEU1125 |
| A | HOH2148 |
| A | HOH2149 |
| A | HOH2150 |
| B | ARG26 |
| O | ARG1110 |
| O | LEU1125 |
| P | ARG26 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2204 |
| Chain | Residue |
| G | TYR1099 |
| G | ASP1149 |
| G | ASN1150 |
| G | SER1187 |
| G | HOH2114 |
| G | HOH2140 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2207 |
| Chain | Residue |
| A | TYR1099 |
| A | ASP1149 |
| A | ASN1150 |
| A | SER1187 |
| A | HOH2117 |
| A | HOH2152 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2208 |
| Chain | Residue |
| A | LYS1092 |
| A | CYS1093 |
| A | ARG1094 |
| A | LYS1161 |
| A | HOH2153 |
| A | HOH2154 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2205 |
| Chain | Residue |
| C | TYR1099 |
| C | ASP1149 |
| C | ASN1150 |
| C | SER1187 |
| C | HOH2109 |
| C | HOH2110 |
| C | HOH2111 |
| C | HOH2113 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2206 |
| Chain | Residue |
| E | ARG1110 |
| E | LEU1125 |
| E | HOH2163 |
| E | HOH2164 |
| E | HOH2165 |
| E | HOH2166 |
| F | ARG26 |
| I | ARG1110 |
| I | LEU1125 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1041 |
| Chain | Residue |
| C | HIS1115 |
| C | HIS1116 |
| C | ARG1180 |
| C | LYS1181 |
| C | ILE1184 |
| D | HIS39 |
| D | ARG40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS23 | |
| D | LYS23 | |
| F | LYS23 | |
| H | LYS23 | |
| J | LYS23 | |
| L | LYS23 | |
| N | LYS23 | |
| P | LYS23 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| B | ARG26 | |
| D | ARG26 | |
| F | ARG26 | |
| H | ARG26 | |
| J | ARG26 | |
| L | ARG26 | |
| N | ARG26 | |
| P | ARG26 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS27 | |
| J | M3L36 | |
| L | LYS27 | |
| L | M3L36 | |
| N | LYS27 | |
| N | M3L36 | |
| P | LYS27 | |
| P | M3L36 | |
| B | M3L36 | |
| D | LYS27 | |
| D | M3L36 | |
| F | LYS27 | |
| F | M3L36 | |
| H | LYS27 | |
| H | M3L36 | |
| J | LYS27 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| B | SER28 | |
| D | SER28 | |
| F | SER28 | |
| H | SER28 | |
| J | SER28 | |
| L | SER28 | |
| N | SER28 | |
| P | SER28 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| B | LYS37 | |
| D | LYS37 | |
| F | LYS37 | |
| H | LYS37 | |
| J | LYS37 | |
| L | LYS37 | |
| N | LYS37 | |
| P | LYS37 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980 |
| Chain | Residue | Details |
| B | TYR41 | |
| D | TYR41 | |
| F | TYR41 | |
| H | TYR41 | |
| J | TYR41 | |
| L | TYR41 | |
| N | TYR41 | |
| P | TYR41 |
