2X4X
Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2206 |
| Chain | Residue |
| A | ARG1110 |
| A | LEU1125 |
| A | HOH2147 |
| A | HOH2148 |
| A | HOH2149 |
| A | HOH2150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS23 | |
| D | LYS23 | |
| F | LYS23 | |
| H | LYS23 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| B | ARG26 | |
| D | ARG26 | |
| F | ARG26 | |
| H | ARG26 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS27 | |
| B | M3L36 | |
| D | LYS27 | |
| D | M3L36 | |
| F | LYS27 | |
| F | M3L36 | |
| H | LYS27 | |
| H | M3L36 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| B | SER28 | |
| D | SER28 | |
| F | SER28 | |
| H | SER28 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| B | LYS37 | |
| D | LYS37 | |
| F | LYS37 | |
| H | LYS37 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980 |
| Chain | Residue | Details |
| B | TYR41 | |
| D | TYR41 | |
| F | TYR41 | |
| H | TYR41 |
