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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2X2F

Dynamin 1 GTPase dimer, short axis form

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
D0003924molecular_functionGTPase activity
D0005525molecular_functionGTP binding
Functional Information from PDB Data
site_idAC1
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GDP A 1747
ChainResidue
ASER41
ALYS206
AASP208
ALEU209
AVAL235
AASN236
AARG237
ASER238
AGLN239
AILE242
AALF1748
AALA42
AMG1749
ANA1750
AHOH2063
AHOH2126
AHOH2171
DASP211
DHOH2094
AGLY43
ALYS44
ASER45
ASER46
AARG59
AGLY60
ASER61
site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ALF A 1748
ChainResidue
AGLN40
ASER41
ALYS44
AGLY62
AVAL64
ATHR65
AGLY139
AGDP1747
AMG1749
ANA1750
AHOH2027
AHOH2063
AHOH2171
site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1749
ChainResidue
ASER45
ATHR65
AGDP1747
AALF1748
AHOH2063
AHOH2171
site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 1750
ChainResidue
ASER41
AGLY60
ASER61
AGLY62
AGDP1747
AALF1748
site_idAC5
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GDP D 1746
ChainResidue
AASP211
AHOH2106
DSER41
DALA42
DGLY43
DLYS44
DSER45
DSER46
DARG59
DGLY60
DSER61
DLYS206
DASP208
DLEU209
DVAL235
DASN236
DARG237
DSER238
DGLN239
DILE242
DALF1747
DMG1748
DNA1749
DHOH2050
DHOH2111
DHOH2150
site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ALF D 1747
ChainResidue
DGLN40
DSER41
DLYS44
DGLY62
DVAL64
DTHR65
DGLY139
DGDP1746
DMG1748
DNA1749
DHOH2020
DHOH2050
DHOH2150
site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG D 1748
ChainResidue
DSER45
DTHR65
DGDP1746
DALF1747
DHOH2050
DHOH2150
site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA D 1749
ChainResidue
DGDP1746
DALF1747
DSER41
DGLY60
DGLY62
Functional Information from PROSITE/UniProt
site_idPS00410
Number of Residues10
DetailsG_DYNAMIN_1 Dynamin-type guanine nucleotide-binding (G) domain signature. LPRGSGIVTR
ChainResidueDetails
ALEU57-ARG66
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30069048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DLU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30069048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DLU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; alternate","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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