2X1L

Crystal structure of Mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine and adenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004825	molecular_function	methionine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006431	biological_process	methionyl-tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004825	molecular_function	methionine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006431	biological_process	methionyl-tRNA aminoacylation
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004825	molecular_function	methionine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006431	biological_process	methionyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MET A 600

Chain	Residue
A	ILE11
A	HIS270
A	ADN601
A	HOH2169
A	HOH2170
A	HOH2171
A	ALA12
A	TYR13
A	ASP50
A	TRP230
A	ALA233
A	LEU234
A	TYR237
A	ILE266

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADN A 601

Chain	Residue
A	ALA10
A	ALA12
A	HIS19
A	GLY21
A	HIS22
A	GLU25
A	GLY263
A	ASP265
A	ILE266
A	HIS292
A	GLY293
A	TRP294
A	LEU295
A	MET600
A	HOH2171

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CXS A 602

Chain	Residue
A	ALA114
A	GLY115
A	ASP116
A	ALA170
A	TYR171
A	ARG174
A	HOH2172
B	TYR452

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 2HP A 603

Chain	Residue
A	PRO188
A	ASP189
A	ARG288
A	VAL406
A	HOH2082
A	HOH2173
A	HOH2174

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MET B 600

Chain	Residue
B	ILE11
B	TYR13
B	ASP50
B	TRP230
B	ALA233
B	TYR237
B	ILE266
B	HIS270
B	ADN601
B	HOH2140
B	HOH2141
B	HOH2142

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADN B 601

Chain	Residue
B	ALA10
B	HIS19
B	GLY21
B	HIS22
B	GLU25
B	GLY263
B	ASP265
B	ILE266
B	HIS292
B	GLY293
B	TRP294
B	LEU295
B	MET600
B	HOH2140
B	HOH2143

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CXS B 602

Chain	Residue
B	ALA114
B	GLY115
B	ASP116
B	ALA170
B	TYR171
B	ARG174
B	HOH2055
C	TYR452
C	ARG495
C	HOH2119

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2HP B 603

Chain	Residue
B	GLY187
B	PRO188
B	ASP189
B	ARG288
B	VAL406
B	HOH2146
B	HOH2147
B	HOH2148

---

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MET C 600

Chain	Residue
C	HOH2158
C	ILE11
C	TYR13
C	ASP50
C	TRP230
C	ALA233
C	TYR237
C	ILE266
C	HIS270
C	ADN601
C	HOH2156

---

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADN C 601

Chain	Residue
C	ALA10
C	ALA12
C	HIS19
C	GLY21
C	HIS22
C	GLU25
C	GLY263
C	ASP265
C	ILE266
C	HIS292
C	GLY293
C	TRP294
C	LEU295
C	MET600
C	HOH2004

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CXS C 602

Chain	Residue
A	TYR452
A	ARG495
C	ALA114
C	ASP116
C	ALA170
C	TYR171
C	ARG174
C	HOH2159
C	HOH2160

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2HP C 603

Chain	Residue
C	GLY187
C	PRO188
C	ASP189
C	ARG288
C	VAL406
C	HOH2068
C	HOH2161
C	HOH2162

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	10
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..NGvPHIGHA

Chain	Residue	Details
A	PRO14-ALA23

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