2X1L
Crystal structure of Mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine and adenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004825 | molecular_function | methionine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| C | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MET A 600 |
| Chain | Residue |
| A | ILE11 |
| A | HIS270 |
| A | ADN601 |
| A | HOH2169 |
| A | HOH2170 |
| A | HOH2171 |
| A | ALA12 |
| A | TYR13 |
| A | ASP50 |
| A | TRP230 |
| A | ALA233 |
| A | LEU234 |
| A | TYR237 |
| A | ILE266 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADN A 601 |
| Chain | Residue |
| A | ALA10 |
| A | ALA12 |
| A | HIS19 |
| A | GLY21 |
| A | HIS22 |
| A | GLU25 |
| A | GLY263 |
| A | ASP265 |
| A | ILE266 |
| A | HIS292 |
| A | GLY293 |
| A | TRP294 |
| A | LEU295 |
| A | MET600 |
| A | HOH2171 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CXS A 602 |
| Chain | Residue |
| A | ALA114 |
| A | GLY115 |
| A | ASP116 |
| A | ALA170 |
| A | TYR171 |
| A | ARG174 |
| A | HOH2172 |
| B | TYR452 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 2HP A 603 |
| Chain | Residue |
| A | PRO188 |
| A | ASP189 |
| A | ARG288 |
| A | VAL406 |
| A | HOH2082 |
| A | HOH2173 |
| A | HOH2174 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MET B 600 |
| Chain | Residue |
| B | ILE11 |
| B | TYR13 |
| B | ASP50 |
| B | TRP230 |
| B | ALA233 |
| B | TYR237 |
| B | ILE266 |
| B | HIS270 |
| B | ADN601 |
| B | HOH2140 |
| B | HOH2141 |
| B | HOH2142 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADN B 601 |
| Chain | Residue |
| B | ALA10 |
| B | HIS19 |
| B | GLY21 |
| B | HIS22 |
| B | GLU25 |
| B | GLY263 |
| B | ASP265 |
| B | ILE266 |
| B | HIS292 |
| B | GLY293 |
| B | TRP294 |
| B | LEU295 |
| B | MET600 |
| B | HOH2140 |
| B | HOH2143 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CXS B 602 |
| Chain | Residue |
| B | ALA114 |
| B | GLY115 |
| B | ASP116 |
| B | ALA170 |
| B | TYR171 |
| B | ARG174 |
| B | HOH2055 |
| C | TYR452 |
| C | ARG495 |
| C | HOH2119 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2HP B 603 |
| Chain | Residue |
| B | GLY187 |
| B | PRO188 |
| B | ASP189 |
| B | ARG288 |
| B | VAL406 |
| B | HOH2146 |
| B | HOH2147 |
| B | HOH2148 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MET C 600 |
| Chain | Residue |
| C | HOH2158 |
| C | ILE11 |
| C | TYR13 |
| C | ASP50 |
| C | TRP230 |
| C | ALA233 |
| C | TYR237 |
| C | ILE266 |
| C | HIS270 |
| C | ADN601 |
| C | HOH2156 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADN C 601 |
| Chain | Residue |
| C | ALA10 |
| C | ALA12 |
| C | HIS19 |
| C | GLY21 |
| C | HIS22 |
| C | GLU25 |
| C | GLY263 |
| C | ASP265 |
| C | ILE266 |
| C | HIS292 |
| C | GLY293 |
| C | TRP294 |
| C | LEU295 |
| C | MET600 |
| C | HOH2004 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CXS C 602 |
| Chain | Residue |
| A | TYR452 |
| A | ARG495 |
| C | ALA114 |
| C | ASP116 |
| C | ALA170 |
| C | TYR171 |
| C | ARG174 |
| C | HOH2159 |
| C | HOH2160 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2HP C 603 |
| Chain | Residue |
| C | GLY187 |
| C | PRO188 |
| C | ASP189 |
| C | ARG288 |
| C | VAL406 |
| C | HOH2068 |
| C | HOH2161 |
| C | HOH2162 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..NGvPHIGHA |
| Chain | Residue | Details |
| A | PRO14-ALA23 |
