2X1C
The crystal structure of precursor acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0042318 | biological_process | penicillin biosynthetic process |
| A | 0050640 | molecular_function | isopenicillin-N N-acyltransferase activity |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0042318 | biological_process | penicillin biosynthetic process |
| B | 0050640 | molecular_function | isopenicillin-N N-acyltransferase activity |
| C | 0005782 | cellular_component | peroxisomal matrix |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0042318 | biological_process | penicillin biosynthetic process |
| C | 0050640 | molecular_function | isopenicillin-N N-acyltransferase activity |
| D | 0005782 | cellular_component | peroxisomal matrix |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
| D | 0042318 | biological_process | penicillin biosynthetic process |
| D | 0050640 | molecular_function | isopenicillin-N N-acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1356 |
| Chain | Residue |
| A | ARG132 |
| A | LYS144 |
| A | VAL341 |
| A | MET342 |
| A | ARG343 |
| A | GOL1360 |
| A | HOH2155 |
| A | HOH2160 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1357 |
| Chain | Residue |
| B | LYS144 |
| B | VAL341 |
| B | MET342 |
| B | ARG343 |
| B | HOH2210 |
| B | HOH2211 |
| B | ARG132 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1357 |
| Chain | Residue |
| A | LEU262 |
| A | ARG302 |
| A | LYS308 |
| A | SER309 |
| A | ARG310 |
| A | HOH2137 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1356 |
| Chain | Residue |
| D | ARG132 |
| D | LYS144 |
| D | VAL341 |
| D | MET342 |
| D | ARG343 |
| D | HOH2062 |
| D | HOH2065 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1358 |
| Chain | Residue |
| A | ARG232 |
| A | LEU250 |
| A | GLN251 |
| A | HOH2161 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1358 |
| Chain | Residue |
| B | ARG232 |
| B | LEU250 |
| B | GLN251 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1359 |
| Chain | Residue |
| A | LYS48 |
| A | ASP79 |
| A | VAL80 |
| A | SER81 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 1356 |
| Chain | Residue |
| B | GLN7 |
| B | GLU12 |
| B | GLU16 |
| B | HOH2008 |
| C | MET1 |
| C | ARG132 |
| C | GLU338 |
| C | PHE340 |
| C | HOH2129 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1359 |
| Chain | Residue |
| B | ASP79 |
| B | VAL80 |
| B | SER81 |
| B | HOH2063 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1360 |
| Chain | Residue |
| B | TYR94 |
| B | GLY95 |
| B | LEU96 |
| B | ARG100 |
| B | HIS170 |
| B | LEU171 |
| B | HOH2070 |
| B | HOH2074 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1361 |
| Chain | Residue |
| B | GLU16 |
| B | HOH2221 |
| C | ARG132 |
| C | LYS144 |
| C | VAL341 |
| C | MET342 |
| C | ARG343 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 1357 |
| Chain | Residue |
| C | ARG175 |
| C | PRO176 |
| C | THR177 |
| D | ARG175 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1360 |
| Chain | Residue |
| A | HIS3 |
| A | THR134 |
| A | ARG136 |
| A | LYS144 |
| A | ASP345 |
| A | ASP348 |
| A | SO41356 |
| A | HOH2155 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1362 |
| Chain | Residue |
| B | PHE340 |
| B | VAL341 |
| B | VAL341 |
| B | HOH2209 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1363 |
| Chain | Residue |
| B | ARG343 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20223213","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X1E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
