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2X19

Crystal structure of Importin13 - RanGTP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0006913biological_processnucleocytoplasmic transport
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006606biological_processprotein import into nucleus
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0031267molecular_functionsmall GTPase binding
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GTP A 1181
ChainResidue
AGLY21
ALYS40
ATYR41
AALA43
ATHR44
AGLY70
ALEU71
AASN124
ALYS125
AASP127
AVAL128
AGLY22
ASER152
AALA153
ALYS154
AMG1182
AHOH2015
AHOH2016
AGLY24
ALYS25
ATHR26
ATHR27
APHE37
AGLU38
ALYS39

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1182
ChainResidue
ATHR26
ATHR44
AGTP1181
AHOH2016

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues164
DetailsDomain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsRegion: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues16
DetailsRegion: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62825","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues32
DetailsRepeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsRepeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues37
DetailsRepeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues32
DetailsRepeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues36
DetailsRepeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues40
DetailsRepeat: {"description":"HEAT 15","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues30
DetailsRepeat: {"description":"HEAT 18","evidences":[{"source":"PubMed","id":"20122403","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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