2X06

SULFOLACTATE DEHYDROGENASE FROM METHANOCALDOCOCCUS JANNASCHII

Replaces:  1RFM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0019295	biological_process	coenzyme M biosynthetic process
A	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
A	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
A	0050545	molecular_function	sulfopyruvate decarboxylase activity
A	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
B	0005737	cellular_component	cytoplasm
B	0016491	molecular_function	oxidoreductase activity
B	0019295	biological_process	coenzyme M biosynthetic process
B	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
B	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
B	0050545	molecular_function	sulfopyruvate decarboxylase activity
B	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
C	0005737	cellular_component	cytoplasm
C	0016491	molecular_function	oxidoreductase activity
C	0019295	biological_process	coenzyme M biosynthetic process
C	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
C	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
C	0050545	molecular_function	sulfopyruvate decarboxylase activity
C	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
D	0005737	cellular_component	cytoplasm
D	0016491	molecular_function	oxidoreductase activity
D	0019295	biological_process	coenzyme M biosynthetic process
D	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
D	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
D	0050545	molecular_function	sulfopyruvate decarboxylase activity
D	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
E	0005737	cellular_component	cytoplasm
E	0016491	molecular_function	oxidoreductase activity
E	0019295	biological_process	coenzyme M biosynthetic process
E	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
E	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
E	0050545	molecular_function	sulfopyruvate decarboxylase activity
E	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
F	0005737	cellular_component	cytoplasm
F	0016491	molecular_function	oxidoreductase activity
F	0019295	biological_process	coenzyme M biosynthetic process
F	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
F	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
F	0050545	molecular_function	sulfopyruvate decarboxylase activity
F	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
G	0005737	cellular_component	cytoplasm
G	0016491	molecular_function	oxidoreductase activity
G	0019295	biological_process	coenzyme M biosynthetic process
G	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
G	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
G	0050545	molecular_function	sulfopyruvate decarboxylase activity
G	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
H	0005737	cellular_component	cytoplasm
H	0016491	molecular_function	oxidoreductase activity
H	0019295	biological_process	coenzyme M biosynthetic process
H	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
H	0047545	molecular_function	(S)-2-hydroxyglutarate dehydrogenase activity
H	0050545	molecular_function	sulfopyruvate decarboxylase activity
H	0102443	molecular_function	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD A 4001

Chain	Residue
A	PHE41
A	PRO158
A	SER171
A	ASP173
A	MSE174
A	ALA175
A	LEU301
A	PRO303
A	GLY304
A	ILE306
A	GLU307
A	HIS44
A	HOH2065
A	HOH2079
B	PRO224
B	LYS225
B	TYR227
A	HIS116
A	PHE117
A	GLY118
A	ILE119
A	ALA120
A	THR140
A	THR156

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD B 4002

Chain	Residue
A	PRO224
A	LYS225
B	PHE41
B	HIS44
B	HIS116
B	GLY118
B	ILE119
B	ALA120
B	THR140
B	THR156
B	PRO158
B	SER171
B	ASP173
B	ALA175
B	LEU301
B	GLY304
B	ILE306
B	GLU307
B	HOH2063

---

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD C 4003

Chain	Residue
C	PHE41
C	HIS44
C	HIS116
C	PHE117
C	GLY118
C	ILE119
C	ALA120
C	THR140
C	THR156
C	SER171
C	ASP173
C	ALA175
C	LEU301
C	GLY304
C	ILE306
C	GLU307
C	HOH2053
D	PHE147
D	LYS225
D	TYR227

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD D 4004

Chain	Residue
C	PHE147
C	PRO224
C	LYS225
C	TYR227
D	PHE41
D	HIS44
D	HIS116
D	PHE117
D	GLY118
D	ALA120
D	THR140
D	THR156
D	SER171
D	ASP173
D	ALA175
D	LEU301
D	GLY304
D	ILE306
D	GLU307
D	HOH2054
D	HOH2055

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD E 4005

Chain	Residue
E	HOH2064
E	HOH2065
F	PRO224
F	LYS225
F	TYR227
E	PHE41
E	HIS44
E	HIS116
E	PHE117
E	GLY118
E	ALA120
E	THR140
E	THR156
E	SER171
E	ASP173
E	ALA175
E	LEU301
E	GLY304
E	ILE306
E	GLU307

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD F 4006

Chain	Residue
E	PRO224
E	LYS225
E	TYR227
F	PHE41
F	HIS44
F	HIS116
F	PHE117
F	GLY118
F	ILE119
F	ALA120
F	THR140
F	THR156
F	ASP173
F	ALA175
F	LEU301
F	PRO303
F	GLY304
F	ILE306
F	GLU307

---

site_id	AC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD G 4007

Chain	Residue
G	PHE41
G	HIS44
G	HIS116
G	PHE117
G	GLY118
G	ALA120
G	THR140
G	THR156
G	PRO158
G	ASP173
G	MSE174
G	ALA175
G	LEU301
G	GLY304
G	ILE306
G	GLU307
G	HOH2064
G	HOH2069
H	LYS225
H	TYR227

---

site_id	AC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD H 4008

Chain	Residue
G	PHE147
G	PRO224
G	LYS225
G	TYR227
G	HOH2040
H	PHE41
H	HIS44
H	HIS116
H	PHE117
H	GLY118
H	ILE119
H	ALA120
H	THR140
H	THR156
H	SER171
H	ASP173
H	ALA175
H	LEU301
H	GLY304
H	ILE306
H	GLU307
H	HOH2052

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15014443","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
A	HIS44

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
B	HIS44

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
C	HIS44

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
D	HIS44

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
E	HIS44

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
F	HIS44

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
G	HIS44

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1s20

Chain	Residue	Details
H	HIS44

---