2X02

CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 AT 1.35 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 1266

Chain	Residue
A	SER67
A	HOH2320
A	HOH2321
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	HOH2060
A	HOH2319

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 A 1267

Chain	Residue
A	SER215
A	ASN216
A	HOH2288
A	HOH2322
A	HOH2324
B	GLN158
B	ARG160
B	HOH2137

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 1266

Chain	Residue
A	HIS87
A	VAL89
B	TYR174
B	LEU175

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 1267

Chain	Residue
B	TYR63
B	LEU64
B	SER209
B	VAL219

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1270

Chain	Residue
A	HOH2324
B	GLU62
B	GLY142
B	HOH2154

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1268

Chain	Residue
A	TYR63
A	LEU64
A	PRO217
A	HOH2053

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 1269

Chain	Residue
A	ASN29
A	PHE32
A	VAL37
A	ASN38
A	GLY39
A	ASN54
A	ASP55

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1268

Chain	Residue
B	ASN29
B	PHE32
B	VAL37
B	ASN38
B	GLY39
B	ASN54
B	ASP55

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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