Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WZY

Crystal structure of A-AChBP in complex with 13-desmethyl spirolide C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SQX A 301

Chain	Residue
A	TYR93
E	ILE118
E	SER167
A	LYS143
A	SER146
A	TRP147
A	VAL148
A	TYR188
A	TYR195
E	TYR55
E	ARG79

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SQX B 301

Chain	Residue
A	GLN38
A	TYR55
A	ARG79
A	ILE118
A	SER167
B	TYR93
B	LYS143
B	SER146
B	TRP147
B	VAL148
B	TYR188
B	CYS191
B	TYR195
B	HOH2095

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SQX C 301

Chain	Residue
B	GLN38
B	TYR55
B	ARG79
B	ILE118
C	TYR93
C	LYS143
C	SER146
C	TRP147
C	VAL148
C	TYR188
C	CYS190
C	CYS191
C	TYR195

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SQX D 301

Chain	Residue
C	TYR55
C	ARG79
C	ILE118
C	SER167
D	TYR93
D	LYS143
D	SER146
D	TRP147
D	VAL148
D	TYR188
D	TYR195
D	HOH2102

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SQX E 301

Chain	Residue
D	TYR55
D	ILE118
E	TYR93
E	LYS143
E	SER146
E	TRP147
E	VAL148
E	TYR195

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SQX F 301

Chain	Residue
F	TYR93
F	LYS143
F	SER146
F	TRP147
F	VAL148
F	TYR188
F	TYR195
F	HOH2086
F	HOH2095
J	TYR55
J	ILE118
J	SER167

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SQX G 301

Chain	Residue
F	TYR55
F	ILE118
F	SER167
F	HOH2020
G	TYR93
G	LYS143
G	SER146
G	TRP147
G	VAL148
G	TYR188
G	TYR195

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SQX H 301

Chain	Residue
G	GLN38
G	TYR55
G	ARG79
G	MET116
G	SER167
H	TYR93
H	LYS143
H	SER146
H	TRP147
H	VAL148
H	TYR188
H	TYR195

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SQX I 301

Chain	Residue
I	SER146
I	TRP147
I	VAL148
I	TYR188
I	TYR195
H	TYR55
H	ARG79
H	ILE118
H	SER167
I	TYR93
I	LYS143

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SQX J 301

Chain	Residue
I	TYR55
I	MET116
I	ILE118
J	TYR93
J	LYS143
J	SER146
J	TRP147
J	VAL148
J	TYR188
J	CYS190
J	CYS191
J	TYR195

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)