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2WZT

Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form

Functional Information from GO Data
ChainGOidnamespacecontents
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Functional Information from PROSITE/UniProt
site_idPS00062
Number of Residues18
DetailsALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LmkvkedgiARSIGVCNF
ChainResidueDetails
ALEU132-PHE149

site_idPS00798
Number of Residues18
DetailsALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRLIDTAaaygnEaaVG
ChainResidueDetails
AGLY48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P80874
ChainResidueDetails
ATYR58
BTYR58

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000269|PubMed:20188740, ECO:0007744|PDB:2WZM
ChainResidueDetails
AGLY196
AASN248
AARG274
BGLY196
BLEU198
BVAL200
BILE236
BARG238
BSER239
BALA240
BARG244
ALEU198
BSER247
BASN248
BARG274
AVAL200
AILE236
AARG238
ASER239
AALA240
AARG244
ASER247

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PDB entries from 2025-06-18

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