2WYW
High resolution structure of Thermus thermophilus enoyl-acyl carrier protein reductase NAD and triclosan-form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD D 1259 |
| Chain | Residue |
| D | GLY15 |
| D | ALA93 |
| D | ILE94 |
| D | ALA95 |
| D | VAL120 |
| D | LEU145 |
| D | THR146 |
| D | LYS164 |
| D | ALA190 |
| D | GLY191 |
| D | PRO192 |
| D | VAL16 |
| D | VAL193 |
| D | THR195 |
| D | ALA197 |
| D | TCL1260 |
| D | HOH2007 |
| D | HOH2129 |
| D | HOH2130 |
| D | HOH2131 |
| D | HOH2132 |
| D | HOH2133 |
| D | THR17 |
| D | HOH2135 |
| D | SER21 |
| D | LEU22 |
| D | GLN42 |
| D | ALA65 |
| D | ASP66 |
| D | VAL67 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TCL D 1260 |
| Chain | Residue |
| D | ALA95 |
| D | ALA97 |
| D | TYR157 |
| D | MET160 |
| D | ALA197 |
| D | ALA198 |
| D | SER200 |
| D | ILE201 |
| D | NAD1259 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAD C 1259 |
| Chain | Residue |
| C | GLY15 |
| C | VAL16 |
| C | THR17 |
| C | SER21 |
| C | LEU22 |
| C | GLN42 |
| C | LEU46 |
| C | ALA65 |
| C | ASP66 |
| C | VAL67 |
| C | ALA93 |
| C | ILE94 |
| C | ALA95 |
| C | PHE96 |
| C | VAL120 |
| C | LEU145 |
| C | THR146 |
| C | LYS164 |
| C | ALA190 |
| C | GLY191 |
| C | PRO192 |
| C | VAL193 |
| C | THR195 |
| C | VAL196 |
| C | ALA197 |
| C | TCL1260 |
| C | HOH2013 |
| C | HOH2085 |
| C | HOH2132 |
| C | HOH2170 |
| C | HOH2171 |
| C | HOH2173 |
| C | HOH2174 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL C 1260 |
| Chain | Residue |
| C | ALA95 |
| C | ALA97 |
| C | TYR157 |
| C | ALA197 |
| C | SER200 |
| C | ILE201 |
| C | NAD1259 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 1259 |
| Chain | Residue |
| B | THR195 |
| B | ALA197 |
| B | TCL1260 |
| B | HOH2011 |
| B | HOH2012 |
| B | HOH2014 |
| B | HOH2159 |
| B | HOH2160 |
| B | HOH2161 |
| B | HOH2162 |
| B | GLY15 |
| B | VAL16 |
| B | THR17 |
| B | SER21 |
| B | LEU22 |
| B | GLN42 |
| B | ALA65 |
| B | ASP66 |
| B | VAL67 |
| B | ALA93 |
| B | ILE94 |
| B | ALA95 |
| B | VAL120 |
| B | LEU145 |
| B | THR146 |
| B | LYS164 |
| B | ALA190 |
| B | GLY191 |
| B | PRO192 |
| B | VAL193 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TCL B 1260 |
| Chain | Residue |
| B | ALA95 |
| B | ALA97 |
| B | TYR157 |
| B | ALA197 |
| B | ILE201 |
| B | NAD1259 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 1260 |
| Chain | Residue |
| A | GLY15 |
| A | VAL16 |
| A | THR17 |
| A | SER21 |
| A | LEU22 |
| A | GLN42 |
| A | ALA65 |
| A | ASP66 |
| A | VAL67 |
| A | ALA93 |
| A | ILE94 |
| A | ALA95 |
| A | VAL120 |
| A | LEU145 |
| A | THR146 |
| A | LYS164 |
| A | ALA190 |
| A | GLY191 |
| A | PRO192 |
| A | VAL193 |
| A | THR195 |
| A | ALA197 |
| A | TCL1261 |
| A | HOH2008 |
| A | HOH2097 |
| A | HOH2200 |
| A | HOH2201 |
| A | HOH2202 |
| A | HOH2203 |
| A | HOH2204 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL A 1261 |
| Chain | Residue |
| A | ALA95 |
| A | ALA97 |
| A | TYR157 |
| A | ALA197 |
| A | ILE201 |
| A | MET207 |
| A | NAD1260 |
