Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WY0

Crystal structure of mouse angiotensinogen in the oxidised form with space group P6122

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000165	biological_process	MAPK cascade
C	0001543	biological_process	ovarian follicle rupture
C	0001568	biological_process	blood vessel development
C	0001658	biological_process	branching involved in ureteric bud morphogenesis
C	0001819	biological_process	positive regulation of cytokine production
C	0001822	biological_process	kidney development
C	0001991	biological_process	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
C	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
C	0001999	biological_process	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
C	0002018	biological_process	renin-angiotensin regulation of aldosterone production
C	0002019	biological_process	regulation of renal output by angiotensin
C	0002027	biological_process	regulation of heart rate
C	0002035	biological_process	brain renin-angiotensin system
C	0003051	biological_process	angiotensin-mediated drinking behavior
C	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
C	0003331	biological_process	positive regulation of extracellular matrix constituent secretion
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006606	biological_process	protein import into nucleus
C	0006883	biological_process	intracellular sodium ion homeostasis
C	0007160	biological_process	cell-matrix adhesion
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0008065	biological_process	establishment of blood-nerve barrier
C	0008217	biological_process	regulation of blood pressure
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008306	biological_process	associative learning
C	0009409	biological_process	response to cold
C	0009651	biological_process	response to salt stress
C	0010468	biological_process	regulation of gene expression
C	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
C	0010628	biological_process	positive regulation of gene expression
C	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
C	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
C	0010976	biological_process	positive regulation of neuron projection development
C	0014061	biological_process	regulation of norepinephrine secretion
C	0014824	biological_process	artery smooth muscle contraction
C	0014873	biological_process	response to muscle activity involved in regulation of muscle adaptation
C	0016525	biological_process	negative regulation of angiogenesis
C	0030103	biological_process	vasopressin secretion
C	0030198	biological_process	extracellular matrix organization
C	0030308	biological_process	negative regulation of cell growth
C	0030432	biological_process	peristalsis
C	0031702	molecular_function	type 1 angiotensin receptor binding
C	0031703	molecular_function	type 2 angiotensin receptor binding
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0034104	biological_process	negative regulation of tissue remodeling
C	0035106	biological_process	operant conditioning
C	0035265	biological_process	organ growth
C	0035932	biological_process	aldosterone secretion
C	0040018	biological_process	positive regulation of multicellular organism growth
C	0042310	biological_process	vasoconstriction
C	0042311	biological_process	vasodilation
C	0042445	biological_process	hormone metabolic process
C	0042756	biological_process	drinking behavior
C	0042981	biological_process	regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043410	biological_process	positive regulation of MAPK cascade
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
C	0045723	biological_process	positive regulation of fatty acid biosynthetic process
C	0045777	biological_process	positive regulation of blood pressure
C	0046622	biological_process	positive regulation of organ growth
C	0046628	biological_process	positive regulation of insulin receptor signaling pathway
C	0048143	biological_process	astrocyte activation
C	0048144	biological_process	fibroblast proliferation
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
C	0048659	biological_process	smooth muscle cell proliferation
C	0048662	biological_process	negative regulation of smooth muscle cell proliferation
C	0050727	biological_process	regulation of inflammatory response
C	0051145	biological_process	smooth muscle cell differentiation
C	0051402	biological_process	neuron apoptotic process
C	0051403	biological_process	stress-activated MAPK cascade
C	0051924	biological_process	regulation of calcium ion transport
C	0051969	biological_process	regulation of transmission of nerve impulse
C	0061049	biological_process	cell growth involved in cardiac muscle cell development
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0070471	biological_process	uterine smooth muscle contraction
C	0097746	biological_process	blood vessel diameter maintenance
C	1901394	biological_process	obsolete positive regulation of transforming growth factor beta1 activation
C	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
C	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
C	1904754	biological_process	positive regulation of vascular associated smooth muscle cell migration
C	1905010	biological_process	positive regulation of L-lysine import across plasma membrane
C	1905589	biological_process	positive regulation of L-arginine import across plasma membrane
C	1990874	biological_process	vascular associated smooth muscle cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 1451

Chain	Residue
C	HIS9
C	HIS13
C	GLU65
C	ARG69

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 1452

Chain	Residue
C	HIS6
C	HOH2101

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 1457

Chain	Residue
C	HOH2002

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 1453

Chain	Residue
C	GLU31

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 1454

Chain	Residue
C	ALA292
C	GLN293
C	ASP291

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1455

Chain	Residue
C	LYS86
C	ASN89
C	PHE328
C	GLN329

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 1456

Chain	Residue
C	TYR12
C	GLY143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN14
C	ASN295
C	ASN377

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)