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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2WXY

Crystal structure of mouse angiotensinogen in the reduced form

Functional Information from GO Data
ChainGOidnamespacecontents
C0001543biological_processovarian follicle rupture
C0001568biological_processblood vessel development
C0001658biological_processbranching involved in ureteric bud morphogenesis
C0001819biological_processpositive regulation of cytokine production
C0001822biological_processkidney development
C0001991biological_processregulation of systemic arterial blood pressure by circulatory renin-angiotensin
C0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
C0001999biological_processrenal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
C0002018biological_processrenin-angiotensin regulation of aldosterone production
C0002019biological_processregulation of renal output by angiotensin
C0002027biological_processregulation of heart rate
C0002033biological_processangiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
C0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
C0002035biological_processbrain renin-angiotensin system
C0003014biological_processrenal system process
C0003051biological_processangiotensin-mediated drinking behavior
C0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
C0003331biological_processpositive regulation of extracellular matrix constituent secretion
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006606biological_processprotein import into nucleus
C0006883biological_processintracellular sodium ion homeostasis
C0007160biological_processcell-matrix adhesion
C0007166biological_processcell surface receptor signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008065biological_processestablishment of blood-nerve barrier
C0008083molecular_functiongrowth factor activity
C0008217biological_processregulation of blood pressure
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008306biological_processassociative learning
C0009409biological_processresponse to cold
C0009651biological_processresponse to salt stress
C0010468biological_processregulation of gene expression
C0010595biological_processpositive regulation of endothelial cell migration
C0010613biological_processpositive regulation of cardiac muscle hypertrophy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
C0010701biological_processpositive regulation of norepinephrine secretion
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010744biological_processpositive regulation of macrophage derived foam cell differentiation
C0010976biological_processpositive regulation of neuron projection development
C0014824biological_processartery smooth muscle contraction
C0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
C0016525biological_processnegative regulation of angiogenesis
C0017080molecular_functionsodium channel regulator activity
C0030103biological_processvasopressin secretion
C0030198biological_processextracellular matrix organization
C0030308biological_processnegative regulation of cell growth
C0030432biological_processperistalsis
C0031702molecular_functiontype 1 angiotensin receptor binding
C0031703molecular_functiontype 2 angiotensin receptor binding
C0032930biological_processpositive regulation of superoxide anion generation
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034104biological_processnegative regulation of tissue remodeling
C0035106biological_processoperant conditioning
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0035932biological_processaldosterone secretion
C0038166biological_processangiotensin-activated signaling pathway
C0040018biological_processpositive regulation of multicellular organism growth
C0042310biological_processvasoconstriction
C0042311biological_processvasodilation
C0042445biological_processhormone metabolic process
C0042756biological_processdrinking behavior
C0042981biological_processregulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043407biological_processnegative regulation of MAP kinase activity
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0045723biological_processpositive regulation of fatty acid biosynthetic process
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045777biological_processpositive regulation of blood pressure
C0045893biological_processpositive regulation of DNA-templated transcription
C0046622biological_processpositive regulation of organ growth
C0046628biological_processpositive regulation of insulin receptor signaling pathway
C0048018molecular_functionreceptor ligand activity
C0048143biological_processastrocyte activation
C0048144biological_processfibroblast proliferation
C0048146biological_processpositive regulation of fibroblast proliferation
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048659biological_processsmooth muscle cell proliferation
C0050727biological_processregulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0051145biological_processsmooth muscle cell differentiation
C0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
C0051403biological_processstress-activated MAPK cascade
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051924biological_processregulation of calcium ion transport
C0051969biological_processregulation of transmission of nerve impulse
C0061049biological_processcell growth involved in cardiac muscle cell development
C0070294biological_processrenal sodium ion absorption
C0070371biological_processERK1 and ERK2 cascade
C0070471biological_processuterine smooth muscle contraction
C0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
C0090205biological_processpositive regulation of cholesterol metabolic process
C0097746biological_processblood vessel diameter maintenance
C0110063biological_processpositive regulation of angiotensin-activated signaling pathway
C1900020biological_processpositive regulation of protein kinase C activity
C1901201biological_processregulation of extracellular matrix assembly
C1901203biological_processpositive regulation of extracellular matrix assembly
C1902632biological_processpositive regulation of membrane hyperpolarization
C1902895biological_processpositive regulation of miRNA transcription
C1903598biological_processpositive regulation of gap junction assembly
C1903779biological_processregulation of cardiac conduction
C1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
C1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
C1905010biological_processpositive regulation of L-lysine import across plasma membrane
C1905589biological_processpositive regulation of L-arginine import across plasma membrane
C1990776biological_processresponse to angiotensin
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
C2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE NA C 1451
ChainResidue
CGLU65
site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO C 1452
ChainResidue
CHIS6
CPRO131
CHOH2034
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO C 1453
ChainResidue
CTYR113
CSER116
CLEU117
CALA121
CNA1458
site_idAC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE NA C 1454
ChainResidue
CGLU31
site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO C 1455
ChainResidue
CTHR126
CPRO131
CVAL132
CHOH2030
site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO C 1456
ChainResidue
CSER290
CASP291
CALA292
CGLN293
site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO C 1457
ChainResidue
CASN89
CPHE328
CGLN329
site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA C 1458
ChainResidue
CTYR12
CLEU114
CLEU141
CGLY143
CEDO1453
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsPeptide: {"description":"Angiotensin-3","featureId":"PRO_0000032463","evidences":[{"source":"UniProtKB","id":"P01019","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues5
DetailsPeptide: {"description":"Angiotensin-4","featureId":"PRO_0000420668","evidences":[{"source":"UniProtKB","id":"P01019","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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