Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WWI

Plasmodium falciparum thymidylate kinase in complex with AZTMP and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004385	molecular_function	guanylate kinase activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004798	molecular_function	thymidylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006177	biological_process	GMP biosynthetic process
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0046710	biological_process	GDP metabolic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
A	0050316	molecular_function	T2-induced deoxynucleotide kinase activity
B	0000166	molecular_function	nucleotide binding
B	0004385	molecular_function	guanylate kinase activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0004798	molecular_function	thymidylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006177	biological_process	GMP biosynthetic process
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0046710	biological_process	GDP metabolic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0050316	molecular_function	T2-induced deoxynucleotide kinase activity
C	0000166	molecular_function	nucleotide binding
C	0004385	molecular_function	guanylate kinase activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0004798	molecular_function	thymidylate kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006177	biological_process	GMP biosynthetic process
C	0006227	biological_process	dUDP biosynthetic process
C	0006233	biological_process	dTDP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0046710	biological_process	GDP metabolic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0050316	molecular_function	T2-induced deoxynucleotide kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ATM A 211

Chain	Residue
A	ASP17
A	GLU151
A	HOH2003
A	PHE44
A	PRO45
A	ARG47
A	PHE74
A	ARG78
A	ARG99
A	GLY104
A	TYR107

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 212

Chain	Residue
A	ARG18
A	SER19
A	GLY20
A	LYS21
A	SER22
A	THR23
A	ARG145
A	ARG182
A	ILE184
A	HOH2014
B	ALA170
B	HIS171

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ATM B 211

Chain	Residue
B	ASP17
B	PRO45
B	ARG47
B	PHE74
B	ARG78
B	ARG99
B	GLY104
B	TYR107

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ADP B 212

Chain	Residue
B	ARG18
B	SER19
B	GLY20
B	LYS21
B	SER22
B	THR23
B	ARG182
B	ILE184
B	HOH2001

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ATM C 211

Chain	Residue
C	ASP17
C	PHE44
C	PRO45
C	ARG47
C	LEU59
C	PHE74
C	ARG78
C	ARG99
C	GLY104
C	TYR107
C	TYR153

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP C 212

Chain	Residue
C	ARG18
C	SER19
C	GLY20
C	LYS21
C	SER22
C	THR23
C	ARG145
C	ARG182
C	ILE184
C	ILE187

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. VCDRYaySGvAYS

Chain	Residue	Details
A	VAL96-SER108

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:20353400, ECO:0007744\|PDB:2WWF

Chain	Residue	Details
A	ASP17
B	ARG78
B	ARG99
B	TYR107
C	ASP17
C	ARG47
C	PHE74
C	ARG78
C	ARG99
C	TYR107
A	ARG47
A	PHE74
A	ARG78
A	ARG99
A	TYR107
B	ASP17
B	ARG47
B	PHE74

site_id	SWS_FT_FI2
Number of Residues	21
Details	BINDING: BINDING => ECO:0000305\|PubMed:20353400, ECO:0007744\|PDB:2WWF, ECO:0007744\|PDB:2WWG, ECO:0007744\|PDB:2WWI

Chain	Residue	Details
A	ARG18
B	GLY20
B	LYS21
B	SER22
B	THR23
B	ARG182
C	ARG18
C	SER19
C	GLY20
C	LYS21
C	SER22
A	SER19
C	THR23
C	ARG182
A	GLY20
A	LYS21
A	SER22
A	THR23
A	ARG182
B	ARG18
B	SER19

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20353400, ECO:0000269\|PubMed:31934749, ECO:0007744\|PDB:2WWG

Chain	Residue	Details
A	SER108
A	TYR153
B	SER108
B	TYR153
C	SER108
C	TYR153

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)