2WWH

Plasmodium falciparum thymidylate kinase in complex with AP5dT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004385	molecular_function	GMP kinase activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004798	molecular_function	dTMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006177	biological_process	GMP biosynthetic process
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046710	biological_process	GDP metabolic process
A	0050316	molecular_function	dGMP kinase activity
B	0000166	molecular_function	nucleotide binding
B	0004385	molecular_function	GMP kinase activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0004798	molecular_function	dTMP kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006177	biological_process	GMP biosynthetic process
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046710	biological_process	GDP metabolic process
B	0050316	molecular_function	dGMP kinase activity
C	0000166	molecular_function	nucleotide binding
C	0004385	molecular_function	GMP kinase activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0004798	molecular_function	dTMP kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006177	biological_process	GMP biosynthetic process
C	0006227	biological_process	dUDP biosynthetic process
C	0006233	biological_process	dTDP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046710	biological_process	GDP metabolic process
C	0050316	molecular_function	dGMP kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE T5A A 211

Chain	Residue
A	ASP17
A	LEU59
A	PHE74
A	ARG78
A	ARG99
A	GLY104
A	TYR107
A	ARG145
A	TYR153
A	ARG182
A	ILE184
A	ARG18
A	NA212
A	NA213
A	HOH2037
A	HOH2061
A	HOH2062
A	HOH2063
B	ALA170
B	HIS171
A	SER19
A	GLY20
A	LYS21
A	SER22
A	THR23
A	PHE44
A	ARG47

---

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE T5A B 211

Chain	Residue
B	ASP17
B	ARG18
B	SER19
B	GLY20
B	LYS21
B	SER22
B	THR23
B	PHE44
B	ARG47
B	LEU59
B	PHE74
B	ARG78
B	ARG99
B	GLY104
B	TYR107
B	ARG145
B	TYR153
B	GLU154
B	ARG182
B	ILE184
B	ILE187
B	NA212
B	HOH2001

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE T5A C 211

Chain	Residue
C	ASP17
C	ARG18
C	SER19
C	GLY20
C	LYS21
C	SER22
C	THR23
C	PHE44
C	PRO45
C	ARG47
C	LEU59
C	PHE74
C	ARG78
C	ARG99
C	SER103
C	GLY104
C	TYR107
C	ARG145
C	ARG182
C	ILE184
C	ILE187
C	NA212
C	NA213
C	HOH2002

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 212

Chain	Residue
A	ASP17
A	GLU151
A	GLU154
A	T5A211

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 213

Chain	Residue
A	SER22
A	ASP98
A	T5A211
A	HOH2037
A	HOH2061

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 212

Chain	Residue
B	SER22
B	ASP98
B	T5A211

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 212

Chain	Residue
C	SER22
C	ASP98
C	T5A211

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 213

Chain	Residue
C	ASP17
C	GLU154
C	T5A211
C	HOH2012

---

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. VCDRYaySGvAYS

Chain	Residue	Details
A	VAL96-SER108

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Region: {"description":"LID","evidences":[{"source":"PubMed","id":"20353400","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20353400","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WWF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20353400","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2WWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WWG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WWI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20353400","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31934749","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WWG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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