2WVH

Structural insights into the pre-reaction state of pyruvate decarboxylase from Zymomonas mobilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
A	0003824	molecular_function	catalytic activity
A	0004737	molecular_function	pyruvate decarboxylase activity
A	0005829	cellular_component	cytosol
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
B	0003824	molecular_function	catalytic activity
B	0004737	molecular_function	pyruvate decarboxylase activity
B	0005829	cellular_component	cytosol
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
E	0003824	molecular_function	catalytic activity
E	0004737	molecular_function	pyruvate decarboxylase activity
E	0005829	cellular_component	cytosol
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
F	0003824	molecular_function	catalytic activity
F	0004737	molecular_function	pyruvate decarboxylase activity
F	0005829	cellular_component	cytosol
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0046872	molecular_function	metal ion binding
V	0000287	molecular_function	magnesium ion binding
V	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
V	0003824	molecular_function	catalytic activity
V	0004737	molecular_function	pyruvate decarboxylase activity
V	0005829	cellular_component	cytosol
V	0016829	molecular_function	lyase activity
V	0016831	molecular_function	carboxy-lyase activity
V	0019752	biological_process	carboxylic acid metabolic process
V	0030976	molecular_function	thiamine pyrophosphate binding
V	0046872	molecular_function	metal ion binding
X	0000287	molecular_function	magnesium ion binding
X	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
X	0003824	molecular_function	catalytic activity
X	0004737	molecular_function	pyruvate decarboxylase activity
X	0005829	cellular_component	cytosol
X	0016829	molecular_function	lyase activity
X	0016831	molecular_function	carboxy-lyase activity
X	0019752	biological_process	carboxylic acid metabolic process
X	0030976	molecular_function	thiamine pyrophosphate binding
X	0046872	molecular_function	metal ion binding
Y	0000287	molecular_function	magnesium ion binding
Y	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
Y	0003824	molecular_function	catalytic activity
Y	0004737	molecular_function	pyruvate decarboxylase activity
Y	0005829	cellular_component	cytosol
Y	0016829	molecular_function	lyase activity
Y	0016831	molecular_function	carboxy-lyase activity
Y	0019752	biological_process	carboxylic acid metabolic process
Y	0030976	molecular_function	thiamine pyrophosphate binding
Y	0046872	molecular_function	metal ion binding
Z	0000287	molecular_function	magnesium ion binding
Z	0000949	biological_process	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
Z	0003824	molecular_function	catalytic activity
Z	0004737	molecular_function	pyruvate decarboxylase activity
Z	0005829	cellular_component	cytosol
Z	0016829	molecular_function	lyase activity
Z	0016831	molecular_function	carboxy-lyase activity
Z	0019752	biological_process	carboxylic acid metabolic process
Z	0030976	molecular_function	thiamine pyrophosphate binding
Z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00187
Number of Residues	20
Details	TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGyavgaPerrnIlMvGDGS

Chain	Residue	Details
A	PHE423-SER442

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	656
Details	Region: {"description":"Thiamine pyrophosphate binding"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {}

Chain

Residue

Details

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