2WVG
Structural insights into the pre-reaction state of pyruvate decarboxylase from Zymomonas mobilis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004737 | molecular_function | pyruvate decarboxylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0030976 | molecular_function | thiamine pyrophosphate binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004737 | molecular_function | pyruvate decarboxylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0030976 | molecular_function | thiamine pyrophosphate binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE F A 569 |
| Chain | Residue |
| A | GLY26 |
| A | ASP27 |
| A | THR72 |
| A | HIS114 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE TPU A 600 |
| Chain | Residue |
| A | GLY439 |
| A | ASP440 |
| A | GLY441 |
| A | SER442 |
| A | ASN467 |
| A | GLY469 |
| A | TYR470 |
| A | THR471 |
| A | ILE472 |
| A | GLU473 |
| A | MG601 |
| A | HOH2443 |
| A | HOH2489 |
| A | HOH2572 |
| B | ALA25 |
| B | GLY26 |
| B | GLU50 |
| B | VAL75 |
| B | HIS114 |
| A | GLY389 |
| A | ASP390 |
| A | GLY413 |
| A | HIS414 |
| A | ILE415 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 601 |
| Chain | Residue |
| A | ASP440 |
| A | ASN467 |
| A | GLY469 |
| A | TPU600 |
| A | HOH2489 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE F B 569 |
| Chain | Residue |
| B | GLY26 |
| B | ASP27 |
| B | THR72 |
| B | HIS114 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE TPU B 600 |
| Chain | Residue |
| A | ALA25 |
| A | GLY26 |
| A | GLU50 |
| A | VAL75 |
| A | HIS114 |
| B | GLY389 |
| B | ASP390 |
| B | GLY413 |
| B | HIS414 |
| B | ILE415 |
| B | GLY439 |
| B | ASP440 |
| B | GLY441 |
| B | SER442 |
| B | ASN467 |
| B | GLY469 |
| B | TYR470 |
| B | THR471 |
| B | ILE472 |
| B | GLU473 |
| B | MG601 |
| B | HOH2409 |
| B | HOH2454 |
| B | HOH2548 |
| B | HOH2549 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | ASP440 |
| B | ASN467 |
| B | GLY469 |
| B | TPU600 |
| B | HOH2448 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE F E 569 |
| Chain | Residue |
| E | GLY26 |
| E | ASP27 |
| E | THR72 |
| E | HIS114 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE TPU E 600 |
| Chain | Residue |
| E | GLY389 |
| E | ASP390 |
| E | GLY413 |
| E | HIS414 |
| E | ILE415 |
| E | GLY439 |
| E | ASP440 |
| E | GLY441 |
| E | SER442 |
| E | ASN467 |
| E | GLY469 |
| E | TYR470 |
| E | THR471 |
| E | ILE472 |
| E | GLU473 |
| E | MG601 |
| E | HOH2478 |
| E | HOH2481 |
| E | HOH2628 |
| E | HOH2629 |
| F | ALA25 |
| F | GLY26 |
| F | GLU50 |
| F | VAL75 |
| F | HIS114 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 601 |
| Chain | Residue |
| E | TPU600 |
| E | HOH2528 |
| E | ASP440 |
| E | ASN467 |
| E | GLY469 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 569 |
| Chain | Residue |
| F | ASP440 |
| F | ASN467 |
| F | GLY469 |
| F | TPU600 |
| F | HOH2497 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE F F 570 |
| Chain | Residue |
| F | GLY26 |
| F | ASP27 |
| F | THR72 |
| F | HIS114 |
| site_id | BC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE TPU F 600 |
| Chain | Residue |
| E | ALA25 |
| E | GLY26 |
| E | GLU50 |
| E | VAL75 |
| E | HIS114 |
| F | GLY389 |
| F | ASP390 |
| F | GLY413 |
| F | HIS414 |
| F | ILE415 |
| F | GLY439 |
| F | ASP440 |
| F | GLY441 |
| F | SER442 |
| F | ASN467 |
| F | GLY469 |
| F | TYR470 |
| F | THR471 |
| F | ILE472 |
| F | GLU473 |
| F | MG569 |
| F | HOH2450 |
| F | HOH2452 |
| F | HOH2497 |
| F | HOH2606 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGyavgaPerrnIlMvGDGS |
| Chain | Residue | Details |
| A | PHE423-SER442 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP27 | |
| F | ASP27 | |
| F | HIS114 | |
| F | GLU473 | |
| A | HIS114 | |
| A | GLU473 | |
| B | ASP27 | |
| B | HIS114 | |
| B | GLU473 | |
| E | ASP27 | |
| E | HIS114 | |
| E | GLU473 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU50 | |
| E | ASP440 | |
| E | ASN467 | |
| E | GLY469 | |
| F | GLU50 | |
| F | ASP440 | |
| F | ASN467 | |
| F | GLY469 | |
| A | ASP440 | |
| A | ASN467 | |
| A | GLY469 | |
| B | GLU50 | |
| B | ASP440 | |
| B | ASN467 | |
| B | GLY469 | |
| E | GLU50 |
