2WVF
Structural and mechanistic insights into Helicobacter pylori NikR function
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010045 | biological_process | response to nickel cation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010045 | biological_process | response to nickel cation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 1148 |
| Chain | Residue |
| A | HIS88 |
| B | HIS99 |
| B | HIS101 |
| B | CYS107 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 1143 |
| Chain | Residue |
| A | HIS101 |
| A | HOH2058 |
| B | HIS88 |
| B | HOH2038 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1144 |
| Chain | Residue |
| A | ARG82 |
| A | ARG82 |
| A | ILE86 |
| A | FMT1146 |
| A | HOH2044 |
| A | HOH2044 |
| B | ARG77 |
| A | GLU78 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1149 |
| Chain | Residue |
| B | ASN80 |
| B | MET83 |
| B | GLN87 |
| B | THR97 |
| B | GLU109 |
| B | ILE111 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 1150 |
| Chain | Residue |
| A | SER142 |
| B | ILE71 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1145 |
| Chain | Residue |
| A | ILE30 |
| A | LYS31 |
| A | GLY33 |
| A | ARG122 |
| A | HOH2085 |
| A | HOH2086 |
| B | GLU78 |
| B | ARG82 |
| B | HOH2004 |
| B | HOH2062 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 1146 |
| Chain | Residue |
| A | GLU78 |
| A | GOL1144 |
| A | HOH2087 |
| A | HOH2088 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 1151 |
| Chain | Residue |
| A | TYR34 |
| B | LYS48 |
| B | ASP52 |
| B | GLY129 |
| B | HOH2076 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 1147 |
| Chain | Residue |
| A | GLN87 |
| A | THR97 |
| A | HIS99 |
| A | HOH2089 |
| A | HOH2090 |
| B | HIS99 |
| B | HIS101 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 1148 |
| Chain | Residue |
| A | ARG77 |
| A | ARG82 |
| A | GLY129 |
| A | ARG131 |
| A | HOH2092 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 1149 |
| Chain | Residue |
| A | THR139 |
| A | LYS140 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 1152 |
| Chain | Residue |
| A | HIS88 |
| B | ASP103 |
| B | GLU104 |
| B | HOH2077 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 1150 |
| Chain | Residue |
| A | ARG37 |
| A | HOH2093 |
| B | ILE11 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1151 |
| Chain | Residue |
| A | GLU39 |
| A | ARG42 |
| A | ASP43 |
| A | ARG46 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1152 |
| Chain | Residue |
| A | SER35 |
| A | GLY91 |
| A | GLU119 |
| A | ARG122 |
| A | HOH2049 |
| A | HOH2094 |
| A | HOH2096 |
| A | HOH2097 |
| B | ARG131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00476 |
| Chain | Residue | Details |
| A | HIS88 | |
| A | HIS99 | |
| A | HIS101 | |
| A | CYS107 | |
| B | HIS88 | |
| B | HIS99 | |
| B | HIS101 | |
| B | CYS107 |
