2WVE
Structural and mechanistic insights into Helicobacter pylori NikR function
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010045 | biological_process | response to nickel cation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010045 | biological_process | response to nickel cation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1142 |
| Chain | Residue |
| B | ARG42 |
| B | ARG46 |
| B | HOH2044 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1143 |
| Chain | Residue |
| B | HOH2046 |
| B | HOH2047 |
| B | HOH2048 |
| A | ARG12 |
| B | SER14 |
| B | SER36 |
| B | ARG37 |
| B | HOH2002 |
| B | HOH2045 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1144 |
| Chain | Residue |
| B | SER36 |
| B | SER38 |
| B | GLU39 |
| B | ARG42 |
| B | HOH2050 |
| B | HOH2051 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1143 |
| Chain | Residue |
| A | HIS93 |
| A | VAL94 |
| B | HIS74 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1144 |
| Chain | Residue |
| A | SER35 |
| A | SER36 |
| A | GLU39 |
| A | ARG42 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1145 |
| Chain | Residue |
| A | LYS48 |
| A | GLN124 |
| A | LYS137 |
| A | GOL1145 |
| B | ARG28 |
| B | TYR34 |
| B | ASP43 |
| B | MET44 |
| B | GLU47 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1145 |
| Chain | Residue |
| A | LYS48 |
| A | GLU51 |
| A | LYS137 |
| A | LYS140 |
| A | HOH2041 |
| B | ARG28 |
| B | ASN32 |
| B | GOL1145 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1146 |
| Chain | Residue |
| A | GLY128 |
| A | LYS134 |
| A | PHE135 |
| A | ALA136 |
| A | HOH2042 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRS A 1147 |
| Chain | Residue |
| A | HIS74 |
| A | HIS75 |
| A | HIS101 |
| A | GLU104 |
| A | HOH2043 |
| B | HIS93 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT A 1148 |
| Chain | Residue |
| A | TYR72 |
| A | HIS74 |
| A | HIS99 |
| A | HIS101 |
| A | HOH2043 |
| B | ILE84 |
| B | THR97 |
| B | HIS99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00476","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
