Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WVD

Structural and mechanistic insights into Helicobacter pylori NikR function

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010045	biological_process	response to nickel cation
A	0016151	molecular_function	nickel cation binding
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010045	biological_process	response to nickel cation
B	0016151	molecular_function	nickel cation binding
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0010045	biological_process	response to nickel cation
C	0016151	molecular_function	nickel cation binding
C	0032993	cellular_component	protein-DNA complex
C	0042802	molecular_function	identical protein binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0010045	biological_process	response to nickel cation
D	0016151	molecular_function	nickel cation binding
D	0032993	cellular_component	protein-DNA complex
D	0042802	molecular_function	identical protein binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1142

Chain	Residue
A	SER36
A	ARG42

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1144

Chain	Residue
B	SER36
B	SER38
B	ARG42

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1145

Chain	Residue
B	HOH2017
C	ARG12
B	ARG37
B	HOH2014
B	HOH2015
B	HOH2016

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1146

Chain	Residue
C	SER36
C	SER38
C	ARG42
C	GLU78

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1146

Chain	Residue
D	SER36
D	ARG42
D	HOH2019

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1147

Chain	Residue
A	ARG12
D	SER36
D	ARG37
D	HOH2004
D	HOH2005

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1143

Chain	Residue
A	TYR72
A	HIS74
A	ASN80
A	HIS99
A	HIS101
A	HOH2009

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 1148

Chain	Residue
A	THR97
A	HIS99
D	TYR72
D	HIS99

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 1146

Chain	Residue
B	ARG42
B	ARG46

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1147

Chain	Residue
C	GLN18
C	ASN20
C	LEU21
D	ARG46

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 1149

Chain	Residue
A	HIS74
A	HIS75
A	HIS101
D	GLN87
D	HIS93
D	VAL94

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 1150

Chain	Residue
A	GLN87
A	HIS88
A	VAL94
D	HIS75
D	HIS101
D	GLU104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00476

Chain	Residue	Details
A	HIS88
C	HIS99
C	HIS101
C	CYS107
D	HIS88
D	HIS99
D	HIS101
D	CYS107
A	HIS99
A	HIS101
A	CYS107
B	HIS88
B	HIS99
B	HIS101
B	CYS107
C	HIS88

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)