2WVC
Structural and mechanistic insights into Helicobacter pylori NikR function
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010045 | biological_process | response to nickel cation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010045 | biological_process | response to nickel cation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 1149 |
| Chain | Residue |
| A | THR139 |
| A | GOL1145 |
| B | LEU138 |
| B | THR139 |
| B | HOH2052 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 1150 |
| Chain | Residue |
| B | HOH2053 |
| A | LYS31 |
| B | ARG82 |
| B | ILE86 |
| B | HOH2027 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT B 1151 |
| Chain | Residue |
| B | ARG77 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1143 |
| Chain | Residue |
| A | GLU78 |
| A | GLN81 |
| A | ARG82 |
| A | LEU130 |
| A | HOH2021 |
| A | HOH2021 |
| A | HOH2051 |
| A | HOH2052 |
| B | ARG77 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1144 |
| Chain | Residue |
| A | ARG82 |
| A | GLY129 |
| A | LEU130 |
| A | ARG131 |
| A | HOH2039 |
| A | HOH2053 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1152 |
| Chain | Residue |
| A | HOH2017 |
| B | MET83 |
| B | GLN87 |
| B | THR97 |
| B | GLU109 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1153 |
| Chain | Residue |
| B | GLY128 |
| B | VAL133 |
| B | PHE135 |
| B | ALA136 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1145 |
| Chain | Residue |
| A | LEU138 |
| A | THR139 |
| A | LYS140 |
| B | LYS137 |
| B | FMT1149 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1154 |
| Chain | Residue |
| A | HIS88 |
| B | GLY74 |
| B | HIS99 |
| B | HIS101 |
| B | CYS107 |
| B | HOH2054 |
| B | HOH2055 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1146 |
| Chain | Residue |
| A | SER36 |
| A | SER38 |
| A | ARG42 |
| B | SER16 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1147 |
| Chain | Residue |
| A | ARG42 |
| A | ASP43 |
| A | ARG46 |
| A | HOH2054 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1155 |
| Chain | Residue |
| A | SER16 |
| B | SER38 |
| B | ARG42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00476 |
| Chain | Residue | Details |
| A | HIS88 | |
| A | HIS99 | |
| A | HIS101 | |
| A | CYS107 | |
| B | HIS88 | |
| B | HIS99 | |
| B | HIS101 | |
| B | CYS107 |
