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2WVC

Structural and mechanistic insights into Helicobacter pylori NikR function

Functional Information from GO Data
ChainGOidnamespacecontents
A0000976molecular_functiontranscription cis-regulatory region binding
A0001217molecular_functionDNA-binding transcription repressor activity
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0006355biological_processregulation of DNA-templated transcription
A0010045biological_processresponse to nickel cation
A0016151molecular_functionnickel cation binding
A0032993cellular_componentprotein-DNA complex
A0042802molecular_functionidentical protein binding
A0043565molecular_functionsequence-specific DNA binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001217molecular_functionDNA-binding transcription repressor activity
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0006355biological_processregulation of DNA-templated transcription
B0010045biological_processresponse to nickel cation
B0016151molecular_functionnickel cation binding
B0032993cellular_componentprotein-DNA complex
B0042802molecular_functionidentical protein binding
B0043565molecular_functionsequence-specific DNA binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT B 1149
ChainResidue
ATHR139
AGOL1145
BLEU138
BTHR139
BHOH2052

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT B 1150
ChainResidue
BHOH2053
ALYS31
BARG82
BILE86
BHOH2027

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE FMT B 1151
ChainResidue
BARG77

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1143
ChainResidue
AGLU78
AGLN81
AARG82
ALEU130
AHOH2021
AHOH2021
AHOH2051
AHOH2052
BARG77

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1144
ChainResidue
AARG82
AGLY129
ALEU130
AARG131
AHOH2039
AHOH2053

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 1152
ChainResidue
AHOH2017
BMET83
BGLN87
BTHR97
BGLU109

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 1153
ChainResidue
BGLY128
BVAL133
BPHE135
BALA136

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 1145
ChainResidue
ALEU138
ATHR139
ALYS140
BLYS137
BFMT1149

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1154
ChainResidue
AHIS88
BGLY74
BHIS99
BHIS101
BCYS107
BHOH2054
BHOH2055

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1146
ChainResidue
ASER36
ASER38
AARG42
BSER16

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1147
ChainResidue
AARG42
AASP43
AARG46
AHOH2054

site_idBC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1155
ChainResidue
ASER16
BSER38
BARG42

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00476
ChainResidueDetails
AHIS88
AHIS99
AHIS101
ACYS107
BHIS88
BHIS99
BHIS101
BCYS107

221051

PDB entries from 2024-06-12

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