2WUW

Crystallographic analysis of counter-ion effects on subtilisin enzymatic action in acetonitrile (native data)

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 1276

Chain	Residue
E	PRO5
E	TYR6
E	ALA52
E	GLY53
E	TYR256
E	SER259

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 1277

Chain	Residue
E	LEU42
E	HOH2017
E	ALA37
E	SER38
E	HIS39

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 1278

Chain	Residue
E	ALA169
E	TYR171
E	VAL174
E	HOH2077
E	HOH2081

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1279

Chain	Residue
E	GLN2
E	ASP41
E	LEU75
E	ASN77
E	THR79
E	VAL81

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CCN E 1280

Chain	Residue
E	LEU126
E	GLY127
E	ALA152
E	GLY154
E	HOH2121

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CCN E 1281

Chain	Residue
E	HIS64
E	ASN218
E	HOH2071

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CCN E 1282

Chain	Residue
E	GLY61
E	ASN62
E	ASN117
E	PRO210
E	HOH2122
E	HOH2123

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CCN E 1283

Chain	Residue
E	TYR143
E	ALA243
E	SER244
E	HOH2124

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CCN E 1284

Chain	Residue
E	THR116
E	ARG145
E	HOH2125

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGIqasH

Chain	Residue	Details
E	VAL28-HIS39

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA

Chain	Residue	Details
E	HIS64-ALA74

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAG

Chain	Residue	Details
E	GLY219-GLY229

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"Peptidase S8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8512925","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---