2WUE

Crystal structure of S114A mutant of HsaD from Mycobacterium tuberculosis in complex with HOPODA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0015994	biological_process	chlorophyll metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0018774	molecular_function	2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
A	0019439	biological_process	obsolete aromatic compound catabolic process
A	0034820	molecular_function	4,9-DSHA hydrolase activity
A	0047746	molecular_function	chlorophyllase activity
A	0051701	biological_process	biological process involved in interaction with host
A	0102296	molecular_function	4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0015994	biological_process	chlorophyll metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0018774	molecular_function	2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
B	0019439	biological_process	obsolete aromatic compound catabolic process
B	0034820	molecular_function	4,9-DSHA hydrolase activity
B	0047746	molecular_function	chlorophyllase activity
B	0051701	biological_process	biological process involved in interaction with host
B	0102296	molecular_function	4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN A 1290

Chain	Residue
A	ARG130
B	TYR127
B	PRO128
B	ALA129
B	ARG130

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KEK B 1289

Chain	Residue
B	ASN54
B	ASN113
B	ALA114
B	LEU115
B	LEU158
B	ARG192
B	MET208
B	PHE212
B	HIS269
B	TRP270
B	HOH2117
B	GLY44
B	GLY45
B	GLY46
B	ALA49

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN A 1291

Chain	Residue
A	TYR127
A	PRO128
A	ALA129
A	ARG130

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	HIS269
B	HIS269

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	GLY45
A	ASN54
A	LEU115
B	GLY45
B	ASN54
B	LEU115

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	ASN113
A	ARG192
A	TRP270
B	ASN113
B	ARG192
B	TRP270

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	ALA114
B	ALA114

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