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2WSW

Crystal Structure of Carnitine Transporter from Proteus mirabilis

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0009437biological_processcarnitine metabolic process
A0015297molecular_functionantiporter activity
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0044667molecular_function(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
A0071705biological_processnitrogen compound transport
A1900749biological_process(R)-carnitine transport
A1900751biological_process4-(trimethylammonio)butanoate transport
A1902270biological_process(R)-carnitine transmembrane transport
A1902603biological_processcarnitine transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 1504
ChainResidue
ATRP147
ATRP323
ATYR327

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CM5 A 1505
ChainResidue
APHE67
ATRP68
APHE71
AARG73

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 1PE A 1506
ChainResidue
AILE333
APHE334
AALA425
AHOH2024
AHOH2052
AILE169
AGLN330

Functional Information from PROSITE/UniProt
site_idPS01303
Number of Residues10
DetailsBCCT BCCT family of transporters signature. AWTVfYWaWW
ChainResidueDetails
AALA315-TRP324

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues272
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:20829798, ECO:0007744|PDB:2WSW
ChainResidueDetails
APRO12-VAL30
ATHR405-THR434
ALEU446-LEU464
ALEU469-LEU492
AVAL43-TRP68
AILE92-ILE112
AGLU132-SER154
AGLY186-THR216
ALEU231-PHE249
AGLN252-GLY277
APHE312-LEU335
ACYS348-ASN369

site_idSWS_FT_FI2
Number of Residues112
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:20829798, ECO:0007744|PDB:2WSW
ChainResidueDetails
AARG31-ALA42
ATYR113-LYS131
AGLU217-GLN230
AGLY278-GLY311
ATHR370-SER404
AALA465-GLY468

site_idSWS_FT_FI3
Number of Residues74
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:20829798, ECO:0007744|PDB:2WSW
ChainResidueDetails
ALEU69-TRP91
AVAL155-ASN185
AGLY250-LEU251
AALA336-LEU347
ACYS435-PRO445

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Important for substrate binding and transport mechanism => ECO:0000305|PubMed:24101465
ChainResidueDetails
AARG262

227111

PDB entries from 2024-11-06

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