2WQM
Structure of apo human Nek7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000922 | cellular_component | spindle pole |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005815 | cellular_component | microtubule organizing center |
| A | 0005874 | cellular_component | microtubule |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032206 | biological_process | positive regulation of telomere maintenance |
| A | 0033044 | biological_process | regulation of chromosome organization |
| A | 0035865 | biological_process | cellular response to potassium ion |
| A | 0043549 | biological_process | regulation of kinase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051225 | biological_process | spindle assembly |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0140677 | molecular_function | molecular function activator activity |
| A | 1900227 | biological_process | positive regulation of NLRP3 inflammasome complex assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1301 |
| Chain | Residue |
| A | ARG23 |
| A | ARG136 |
| A | THR137 |
| A | LYS140 |
| A | HOH2178 |
| A | HOH2179 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 1302 |
| Chain | Residue |
| A | CYS247 |
| A | HIS209 |
| A | HIS209 |
| A | CYS247 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGQFSEVYrAaclldgvp..........VALK |
| Chain | Residue | Details |
| A | ILE40-LYS63 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VmHrDIKpaNVFI |
| Chain | Residue | Details |
| A | VAL157-ILE169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"NTE motif","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2WQN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Autoinhibitory","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP161 | |
| A | ALA165 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP161 | |
| A | LYS163 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | THR199 | |
| A | ASP161 | |
| A | LYS163 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASN166 | |
| A | ASP161 | |
| A | LYS163 |
