Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0031012 | cellular_component | extracellular matrix |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 023 B 1267 |
| Chain | Residue |
| A | GLN259 |
| B | GLU219 |
| B | HIS222 |
| B | HIS228 |
| B | PRO238 |
| B | THR239 |
| B | TYR240 |
| B | LYS241 |
| B | ZN1268 |
| B | HOH2186 |
| D | GOL1272 |
| A | SER260 |
| B | GLY179 |
| B | ILE180 |
| B | LEU181 |
| B | ALA182 |
| B | LEU214 |
| B | THR215 |
| B | HIS218 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 023 D 1266 |
| Chain | Residue |
| C | GLN259 |
| C | SER260 |
| D | GLY179 |
| D | ILE180 |
| D | LEU181 |
| D | ALA182 |
| D | LEU214 |
| D | THR215 |
| D | HIS218 |
| D | GLU219 |
| D | HIS222 |
| D | HIS228 |
| D | PRO238 |
| D | THR239 |
| D | TYR240 |
| D | LYS241 |
| D | ZN1267 |
| D | GOL1271 |
| D | HOH2142 |
| D | HOH2143 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1268 |
| Chain | Residue |
| A | HIS218 |
| A | HIS222 |
| A | HIS228 |
| A | 0681271 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1269 |
| Chain | Residue |
| A | HIS168 |
| A | ASP170 |
| A | HIS183 |
| A | HIS196 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1270 |
| Chain | Residue |
| A | ASP175 |
| A | GLY176 |
| A | GLY178 |
| A | ILE180 |
| A | ASP198 |
| A | GLU201 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1268 |
| Chain | Residue |
| B | HIS218 |
| B | HIS222 |
| B | HIS228 |
| B | 0231267 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1269 |
| Chain | Residue |
| B | HIS168 |
| B | ASP170 |
| B | HIS183 |
| B | HIS196 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1270 |
| Chain | Residue |
| B | ASP175 |
| B | GLY176 |
| B | GLY178 |
| B | ILE180 |
| B | ASP198 |
| B | GLU201 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1271 |
| Chain | Residue |
| B | ASP158 |
| B | GLY190 |
| B | GLY192 |
| B | ASP194 |
| B | HOH2069 |
| B | HOH2103 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1272 |
| Chain | Residue |
| B | ASP124 |
| B | GLU199 |
| B | GLU201 |
| B | HOH2113 |
| B | HOH2118 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1269 |
| Chain | Residue |
| C | HIS218 |
| C | HIS222 |
| C | HIS228 |
| C | 0681272 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1270 |
| Chain | Residue |
| C | HIS168 |
| C | ASP170 |
| C | HIS183 |
| C | HIS196 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1271 |
| Chain | Residue |
| C | ASP175 |
| C | GLY176 |
| C | GLY178 |
| C | ILE180 |
| C | ASP198 |
| C | GLU201 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1267 |
| Chain | Residue |
| D | HIS218 |
| D | HIS222 |
| D | HIS228 |
| D | 0231266 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1268 |
| Chain | Residue |
| D | HIS196 |
| D | HIS168 |
| D | ASP170 |
| D | HIS183 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 1269 |
| Chain | Residue |
| D | ASP175 |
| D | GLY176 |
| D | GLY178 |
| D | ILE180 |
| D | ASP198 |
| D | GLU201 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 1270 |
| Chain | Residue |
| D | ASP124 |
| D | GLU199 |
| D | GLU201 |
| D | HOH2012 |
| site_id | BC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 068 A 1271 |
| Chain | Residue |
| A | ILE180 |
| A | LEU181 |
| A | ALA182 |
| A | LEU214 |
| A | HIS218 |
| A | GLU219 |
| A | HIS222 |
| A | HIS228 |
| A | LYS233 |
| A | VAL235 |
| A | PHE237 |
| A | PRO238 |
| A | THR239 |
| A | TYR240 |
| A | LYS241 |
| A | VAL243 |
| A | PHE248 |
| A | ZN1268 |
| A | HOH2145 |
| A | HOH2162 |
| A | HOH2163 |
| A | HOH2164 |
| site_id | CC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 068 C 1272 |
| Chain | Residue |
| C | LEU181 |
| C | ALA182 |
| C | LEU214 |
| C | HIS218 |
| C | GLU219 |
| C | HIS222 |
| C | HIS228 |
| C | LYS233 |
| C | ALA234 |
| C | VAL235 |
| C | PHE237 |
| C | THR239 |
| C | TYR240 |
| C | VAL243 |
| C | PHE248 |
| C | ZN1269 |
| C | HOH2093 |
| C | HOH2153 |
| C | HOH2154 |
| C | HOH2155 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 1271 |
| Chain | Residue |
| B | SER207 |
| B | GLY209 |
| B | TYR240 |
| B | TYR242 |
| D | LEU181 |
| D | THR210 |
| D | 0231266 |
| D | HOH2144 |
| D | HOH2146 |
| site_id | CC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 1272 |
| Chain | Residue |
| B | LEU181 |
| B | THR210 |
| B | 0231267 |
| D | SER207 |
| D | GLY208 |
| D | GLY209 |
| D | TYR240 |
| D | TYR242 |
| D | HOH2145 |
| D | HOH2146 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 1273 |
| Chain | Residue |
| B | ARG249 |
| B | HOH2155 |
| C | ALA252 |
| C | HOH2156 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1273 |
| Chain | Residue |
| A | ARG110 |
| B | ALA167 |
| B | HIS168 |
| B | GLY169 |
| B | ASP170 |
| B | PHE171 |
| B | HIS172 |
| B | ALA173 |
| B | HOH2187 |
| B | HOH2188 |
| B | HOH2189 |
| B | HOH2190 |
| B | HOH2191 |
| site_id | CC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1274 |
| Chain | Residue |
| C | ARG110 |
| C | HOH2157 |
| C | HOH2158 |
| C | HOH2159 |
| C | HOH2160 |
| D | ALA167 |
| D | HIS168 |
| D | GLY169 |
| D | ASP170 |
| D | PHE171 |
| D | HIS172 |
| D | ALA173 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1273 |
| Chain | Residue |
| D | ARG135 |
| D | LYS136 |
| D | GLN139 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1274 |
| Chain | Residue |
| D | ARG117 |
| D | THR154 |
| D | GLY155 |
| D | ARG256 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1272 |
| Chain | Residue |
| A | ALA167 |
| A | HIS168 |
| A | GLY169 |
| A | ASP170 |
| A | PHE171 |
| A | HOH2092 |
| A | HOH2094 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1273 |
| Chain | Residue |
| A | ARG135 |
| A | LYS136 |
| A | GLN139 |
| A | HOH2165 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1274 |
| Chain | Residue |
| A | ARG117 |
| A | THR154 |
| A | GLY155 |
| D | GLY190 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1274 |
| Chain | Residue |
| B | ARG135 |
| B | LYS136 |
| B | GLN139 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1275 |
| Chain | Residue |
| B | ARG117 |
| B | THR154 |
| B | GLY155 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
| Chain | Residue | Details |
| A | THR215-LEU224 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU219 | |
| B | GLU219 | |
| C | GLU219 | |
| D | GLU219 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP124 | |
| A | GLY190 | |
| A | GLY192 | |
| A | ASP194 | |
| A | HIS196 | |
| A | ASP198 | |
| A | GLU199 | |
| A | GLU201 | |
| A | HIS218 | |
| A | HIS222 | |
| A | HIS228 | |
| A | ASP158 | |
| B | ASP124 | |
| B | ASP158 | |
| B | HIS168 | |
| B | ASP170 | |
| B | ASP175 | |
| B | GLY176 | |
| B | GLY178 | |
| B | ILE180 | |
| B | HIS183 | |
| B | GLY190 | |
| A | HIS168 | |
| B | GLY192 | |
| B | ASP194 | |
| B | HIS196 | |
| B | ASP198 | |
| B | GLU199 | |
| B | GLU201 | |
| B | HIS218 | |
| B | HIS222 | |
| B | HIS228 | |
| C | ASP124 | |
| A | ASP170 | |
| C | ASP158 | |
| C | HIS168 | |
| C | ASP170 | |
| C | ASP175 | |
| C | GLY176 | |
| C | GLY178 | |
| C | ILE180 | |
| C | HIS183 | |
| C | GLY190 | |
| C | GLY192 | |
| A | ASP175 | |
| C | ASP194 | |
| C | HIS196 | |
| C | ASP198 | |
| C | GLU199 | |
| C | GLU201 | |
| C | HIS218 | |
| C | HIS222 | |
| C | HIS228 | |
| D | ASP124 | |
| D | ASP158 | |
| A | GLY176 | |
| D | HIS168 | |
| D | ASP170 | |
| D | ASP175 | |
| D | GLY176 | |
| D | GLY178 | |
| D | ILE180 | |
| D | HIS183 | |
| D | GLY190 | |
| D | GLY192 | |
| D | ASP194 | |
| A | GLY178 | |
| D | HIS196 | |
| D | ASP198 | |
| D | GLU199 | |
| D | GLU201 | |
| D | HIS218 | |
| D | HIS222 | |
| D | HIS228 | |
| A | ILE180 | |
| A | HIS183 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET236 | |
| A | GLU219 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | MET236 | |
| B | GLU219 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | MET236 | |
| C | GLU219 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| D | MET236 | |
| D | GLU219 | |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU219 | |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU219 | |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | GLU219 | |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| D | GLU219 | |
