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2WMZ

Structure of a mutated TolC

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0009279cellular_componentcell outer membrane
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0015125molecular_functionbile acid transmembrane transporter activity
A0015288molecular_functionporin activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015721biological_processbile acid and bile salt transport
A0016020cellular_componentmembrane
A0019867cellular_componentouter membrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042930biological_processenterobactin transport
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
A0098567cellular_componentperiplasmic side of plasma membrane
A0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
A1990196cellular_componentMacAB-TolC complex
A1990281cellular_componentefflux pump complex
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0009279cellular_componentcell outer membrane
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0015125molecular_functionbile acid transmembrane transporter activity
B0015288molecular_functionporin activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015721biological_processbile acid and bile salt transport
B0016020cellular_componentmembrane
B0019867cellular_componentouter membrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042930biological_processenterobactin transport
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
B0098567cellular_componentperiplasmic side of plasma membrane
B0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
B1990196cellular_componentMacAB-TolC complex
B1990281cellular_componentefflux pump complex
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0009279cellular_componentcell outer membrane
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0015125molecular_functionbile acid transmembrane transporter activity
C0015288molecular_functionporin activity
C0015562molecular_functionefflux transmembrane transporter activity
C0015721biological_processbile acid and bile salt transport
C0016020cellular_componentmembrane
C0019867cellular_componentouter membrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0042930biological_processenterobactin transport
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
C0098567cellular_componentperiplasmic side of plasma membrane
C0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
C1990196cellular_componentMacAB-TolC complex
C1990281cellular_componentefflux pump complex
C1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1429
ChainResidue
AGLN294
AGLY296
AMET297
AVAL298

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PGE A 1430
ChainResidue
ALEU42
AGLY43
BHOH2009

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1429
ChainResidue
BMET297
BVAL298
BGLN294
BGLY296

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA B 1430
ChainResidue
BGLU180
CASN332

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PGE B 1431
ChainResidue
BLEU42
BGLY43

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PGE B 1432
ChainResidue
BGLN236
BGLN301
BASN308

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL C 1429
ChainResidue
CGLN294
CGLY296
CMET297
CVAL298

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PGE C 1430
ChainResidue
CGLN236
CALA305
CASN308

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PGE C 1431
ChainResidue
ASER289
CGLY43

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues630
DetailsTOPO_DOM: Periplasmic
ChainResidueDetails
AGLU1-PRO40
AILE75-PRO246
BGLU1-PRO40
BILE75-PRO246
CGLU1-PRO40
CILE75-PRO246

site_idSWS_FT_FI2
Number of Residues33
DetailsTRANSMEM: Beta stranded; Name=S1
ChainResidueDetails
AGLN41-ASN52
BGLN41-ASN52
CGLN41-ASN52

site_idSWS_FT_FI3
Number of Residues81
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AGLY53-ILE60
AASP258-ASN278
BGLY53-ILE60
BASP258-ASN278
CGLY53-ILE60
CASP258-ASN278

site_idSWS_FT_FI4
Number of Residues39
DetailsTRANSMEM: Beta stranded; Name=S2
ChainResidueDetails
AASN61-SER74
BASN61-SER74
CASN61-SER74

site_idSWS_FT_FI5
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S4
ChainResidueDetails
ATHR247-SER257
BTHR247-SER257
CTHR247-SER257

site_idSWS_FT_FI6
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S5
ChainResidueDetails
AMET279-SER289
BMET279-SER289
CMET279-SER289

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PDB entries from 2024-04-24

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