2WM4
X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0010430 | biological_process | fatty acid omega-oxidation |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0031073 | molecular_function | cholesterol 26-hydroxylase activity |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0097089 | biological_process | methyl-branched fatty acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 450 |
| Chain | Residue |
| A | ILE111 |
| A | ARG320 |
| A | TYR343 |
| A | GLY370 |
| A | PHE371 |
| A | HIS377 |
| A | CYS379 |
| A | GLY381 |
| A | ALA385 |
| A | VGJ1429 |
| A | HOH2135 |
| A | HIS118 |
| A | HOH2144 |
| A | HOH2173 |
| A | HOH2174 |
| A | ARG122 |
| A | ILE176 |
| A | LEU264 |
| A | ALA267 |
| A | THR271 |
| A | THR272 |
| A | VAL315 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE VGJ A 1429 |
| Chain | Residue |
| A | LEU60 |
| A | PHE63 |
| A | ASN97 |
| A | LEU198 |
| A | HEM450 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1430 |
| Chain | Residue |
| A | ASN156 |
| A | ASP158 |
| A | GLN160 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"19933331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WM5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1akd |
| Chain | Residue | Details |
| A | GLU270 | |
| A | THR271 |
