2WLT

The crystal structure of Helicobacter pylori L-asparaginase at 1.4 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004067	molecular_function	asparaginase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006528	biological_process	asparagine metabolic process
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ASP A 1333

Chain	Residue
A	GLY15
A	ALA120
A	ASN255
A	GLU289
A	HOH2107
A	HOH2137
A	THR16
A	SER31
A	GLY61
A	SER62
A	GLN63
A	GLY94
A	THR95
A	ASP96

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Functional Information from PROSITE/UniProt

site_id	PS00144
Number of Residues	9
Details	ASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. LlATGGTIA

Chain	Residue	Details
A	LEU10-ALA18

---

site_id	PS00917
Number of Residues	11
Details	ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GvVitHGTDTL

Chain	Residue	Details
A	GLY88-LEU98

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"O-isoaspartyl threonine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10099","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10100","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	THR95
A	THR16
A	ASP96
A	TYR29
A	LYS168

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	THR95
A	THR16
A	TYR29

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	GLU289

---