2WKT
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE N316A MUTANT WITH COENZYME A.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006635 | biological_process | fatty acid beta-oxidation |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006635 | biological_process | fatty acid beta-oxidation |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006635 | biological_process | fatty acid beta-oxidation |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006635 | biological_process | fatty acid beta-oxidation |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1393 |
Chain | Residue |
A | SER260 |
A | ALA262 |
A | ARG266 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 1393 |
Chain | Residue |
B | HOH2414 |
B | HOH2415 |
B | SER260 |
B | GLU263 |
B | ARG266 |
B | HOH2162 |
B | HOH2412 |
B | HOH2413 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 1394 |
Chain | Residue |
B | LYS298 |
B | ARG302 |
B | HOH2344 |
B | HOH2416 |
B | HOH2417 |
B | HOH2418 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1394 |
Chain | Residue |
A | LYS298 |
A | GLU301 |
A | ARG302 |
A | HOH2432 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 D 1393 |
Chain | Residue |
D | LYS298 |
D | ARG302 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 1395 |
Chain | Residue |
B | GLN167 |
B | TRP168 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 1394 |
Chain | Residue |
D | ARG41 |
D | ILE199 |
D | VAL200 |
D | PRO201 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 1396 |
Chain | Residue |
B | ARG41 |
B | VAL200 |
B | HOH2057 |
B | HOH2251 |
B | HOH2421 |
B | HOH2422 |
B | HOH2423 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 1397 |
Chain | Residue |
B | ARG368 |
B | HOH2384 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 1395 |
Chain | Residue |
A | GLN56 |
A | CL1396 |
B | HOH2127 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA C 1393 |
Chain | Residue |
C | VAL52 |
C | ILE53 |
C | LEU54 |
C | ALA67 |
C | TRP83 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 1396 |
Chain | Residue |
A | LEU54 |
A | GLY55 |
A | GLN56 |
A | GLY84 |
A | MET85 |
A | K1395 |
site_id | BC4 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE COA A 1397 |
Chain | Residue |
A | CSO89 |
A | LEU148 |
A | HIS156 |
A | MET157 |
A | ARG220 |
A | SER227 |
A | MET228 |
A | LEU231 |
A | PHE235 |
A | GLY244 |
A | SER247 |
A | MET288 |
A | PHE319 |
A | HIS348 |
A | HOH2289 |
A | HOH2300 |
A | HOH2322 |
A | HOH2324 |
A | HOH2325 |
A | HOH2434 |
A | HOH2435 |
A | HOH2436 |
A | HOH2439 |
A | HOH2440 |
C | LYS208 |
D | LYS133 |
site_id | BC5 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE COA B 1398 |
Chain | Residue |
B | HOH2424 |
B | HOH2425 |
B | HOH2426 |
B | HOH2427 |
B | HOH2428 |
B | HOH2429 |
B | HOH2430 |
C | MET134 |
B | CSO89 |
B | LEU148 |
B | HIS156 |
B | MET157 |
B | ARG220 |
B | SER227 |
B | MET228 |
B | LEU231 |
B | PHE235 |
B | ALA243 |
B | GLY244 |
B | SER247 |
B | LEU249 |
B | MET288 |
B | PHE319 |
B | HOH2282 |
B | HOH2284 |
B | HOH2290 |
B | HOH2306 |
B | HOH2307 |
B | HOH2309 |
site_id | BC6 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE COA C 1394 |
Chain | Residue |
A | LYS208 |
C | CYS89 |
C | LEU148 |
C | HIS156 |
C | MET157 |
C | ARG220 |
C | SER227 |
C | MET228 |
C | LEU231 |
C | ALA243 |
C | GLY244 |
C | SER247 |
C | MET288 |
C | ALA318 |
C | PHE319 |
C | HOH2170 |
C | HOH2182 |
C | HOH2183 |
C | HOH2254 |
site_id | BC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE COA D 1395 |
Chain | Residue |
A | MET134 |
D | CSO89 |
D | LEU148 |
D | HIS156 |
D | MET157 |
D | ARG220 |
D | SER227 |
D | LEU231 |
D | PHE235 |
D | ALA243 |
D | GLY244 |
D | SER247 |
D | GLY248 |
D | LEU249 |
D | MET288 |
D | ALA318 |
D | PHE319 |
D | HIS348 |
D | HOH2114 |
D | HOH2164 |
D | HOH2165 |
D | HOH2196 |
D | HOH2215 |
D | HOH2216 |
D | HOH2218 |
Functional Information from PROSITE/UniProt
site_id | PS00098 |
Number of Residues | 19 |
Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. MNQlCGSGLrAValgmqqI |
Chain | Residue | Details |
C | MET85-ILE103 | |
A | MET85-ILE103 |
site_id | PS00099 |
Number of Residues | 14 |
Details | THIOLASE_3 Thiolases active site. GLATLCIGgGmGvA |
Chain | Residue | Details |
C | GLY373-ALA386 | |
A | GLY373-ALA386 |
site_id | PS00737 |
Number of Residues | 17 |
Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAiGHPiGaSG |
Chain | Residue | Details |
C | ASN338-GLY354 | |
A | ASN338-GLY354 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Acyl-thioester intermediate |
Chain | Residue | Details |
C | CYS89 | |
B | CSO89 | |
D | CSO89 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
C | HIS348 | |
C | CYS378 | |
B | HIS348 | |
B | CYS378 | |
D | HIS348 | |
D | CYS378 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
A | HIS348 | |
A | GLY380 | |
A | CYS378 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
B | HIS348 | |
B | GLY380 | |
B | CYS378 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
D | HIS348 | |
D | GLY380 | |
D | CYS378 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
C | HIS348 | |
C | GLY380 | |
C | CYS378 | |
C | CYS89 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
A | HIS348 | |
A | CYS378 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
B | HIS348 | |
B | CYS378 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
D | HIS348 | |
D | CYS378 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1afw |
Chain | Residue | Details |
C | HIS348 | |
C | CYS378 |