2WKH

Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ZZ7 A 1265

Chain	Residue
A	ALA66
A	GLY207
A	PHE208
A	SER209
A	LEU247
A	ARG250
A	HOH2125
A	HOH2136
A	HOH2148
A	SER67
A	MET99
A	TRP102
A	SER115
A	VAL117
A	GLU129
A	LEU155
A	THR206

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1266

Chain	Residue
A	ARG160
A	HOH2150
A	HOH2151

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1267

Chain	Residue
A	MET99
A	LYS100
A	SER147
A	GLY148
A	HOH2152
A	HOH2153

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1268

Chain	Residue
A	SER67
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ZZ7 B 1265

Chain	Residue
B	ALA66
B	SER67
B	MET99
B	SER115
B	VAL117
B	GLY207
B	PHE208
B	SER209
B	GLY210
B	ARG250

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1266

Chain	Residue
B	THR80
B	ARG131
B	LYS134
B	TYR135

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1267

Chain	Residue
B	SER67
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---