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2WK6

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil

Functional Information from GO Data
ChainGOidnamespacecontents
A0000002biological_processmitochondrial genome maintenance
A0001525biological_processangiogenesis
A0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006206biological_processpyrimidine nucleobase metabolic process
A0006213biological_processpyrimidine nucleoside metabolic process
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0009032molecular_functionthymidine phosphorylase activity
A0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
A0016757molecular_functionglycosyltransferase activity
A0016763molecular_functionpentosyltransferase activity
A0030154biological_processcell differentiation
A0031641biological_processregulation of myelination
A0042803molecular_functionprotein homodimerization activity
A0046074biological_processdTMP catabolic process
A0051969biological_processregulation of transmission of nerve impulse
A1905333biological_processregulation of gastric motility
B0000002biological_processmitochondrial genome maintenance
B0001525biological_processangiogenesis
B0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006206biological_processpyrimidine nucleobase metabolic process
B0006213biological_processpyrimidine nucleoside metabolic process
B0006935biological_processchemotaxis
B0007165biological_processsignal transduction
B0008083molecular_functiongrowth factor activity
B0009032molecular_functionthymidine phosphorylase activity
B0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
B0016757molecular_functionglycosyltransferase activity
B0016763molecular_functionpentosyltransferase activity
B0030154biological_processcell differentiation
B0031641biological_processregulation of myelination
B0042803molecular_functionprotein homodimerization activity
B0046074biological_processdTMP catabolic process
B0051969biological_processregulation of transmission of nerve impulse
B1905333biological_processregulation of gastric motility
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE IUR A 1482
ChainResidue
AHIS116
AVAL241
ATHR118
ALEU148
ATYR199
AARG202
AILE214
ASER217
AILE218
ALYS221

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE IUR B 1482
ChainResidue
BHIS116
BSER117
BTHR118
BLEU148
BTYR199
BARG202
BILE214
BSER217
BILE218
BLYS221
BVAL241

Functional Information from PROSITE/UniProt
site_idPS00647
Number of Residues16
DetailsTHYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE
ChainResidueDetails
ASER144-GLU159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AHIS116
AARG202
ASER217
ALYS221
BHIS116
BARG202
BSER217
BLYS221

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q5FVR2
ChainResidueDetails
ATHR6
BTHR6

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
ALYS221
AHIS116
AARG202

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
BLYS221
BHIS116
BARG202

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
ALYS221
AHIS116
ASER217
AARG202

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
BLYS221
BHIS116
BSER217
BARG202

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PDB entries from 2024-09-18

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