2WK6

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0004645	molecular_function	1,4-alpha-oligoglucan phosphorylase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006206	biological_process	pyrimidine nucleobase metabolic process
A	0006213	biological_process	pyrimidine nucleoside metabolic process
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0008083	molecular_function	growth factor activity
A	0009032	molecular_function	thymidine phosphorylase activity
A	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0030154	biological_process	cell differentiation
A	0042803	molecular_function	protein homodimerization activity
A	0046074	biological_process	dTMP catabolic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072527	biological_process	pyrimidine-containing compound metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0001525	biological_process	angiogenesis
B	0004645	molecular_function	1,4-alpha-oligoglucan phosphorylase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006206	biological_process	pyrimidine nucleobase metabolic process
B	0006213	biological_process	pyrimidine nucleoside metabolic process
B	0006935	biological_process	chemotaxis
B	0007165	biological_process	signal transduction
B	0008083	molecular_function	growth factor activity
B	0009032	molecular_function	thymidine phosphorylase activity
B	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0030154	biological_process	cell differentiation
B	0042803	molecular_function	protein homodimerization activity
B	0046074	biological_process	dTMP catabolic process
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072527	biological_process	pyrimidine-containing compound metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IUR A 1482

Chain	Residue
A	HIS116
A	VAL241
A	THR118
A	LEU148
A	TYR199
A	ARG202
A	ILE214
A	SER217
A	ILE218
A	LYS221

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE IUR B 1482

Chain	Residue
B	HIS116
B	SER117
B	THR118
B	LEU148
B	TYR199
B	ARG202
B	ILE214
B	SER217
B	ILE218
B	LYS221
B	VAL241

---

Functional Information from PROSITE/UniProt

site_id	PS00647
Number of Residues	16
Details	THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE

Chain	Residue	Details
A	SER144-GLU159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Repeat: {"description":"R-V-A-A-A-L-X(5,6)-L-G-R"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	32
Details	Repeat: {"description":"R-A-L-X-X-A-L-V-L"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1azy

Chain	Residue	Details
A	LYS221
A	HIS116
A	ARG202

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1azy

Chain	Residue	Details
B	LYS221
B	HIS116
B	ARG202

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1azy

Chain	Residue	Details
A	LYS221
A	HIS116
A	SER217
A	ARG202

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1azy

Chain	Residue	Details
B	LYS221
B	HIS116
B	SER217
B	ARG202

---