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2WK5

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil

Functional Information from GO Data
ChainGOidnamespacecontents
A0000002biological_processmitochondrial genome maintenance
A0001525biological_processangiogenesis
A0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006206biological_processpyrimidine nucleobase metabolic process
A0006213biological_processpyrimidine nucleoside metabolic process
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0009032molecular_functionthymidine phosphorylase activity
A0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
A0016757molecular_functionglycosyltransferase activity
A0016763molecular_functionpentosyltransferase activity
A0030154biological_processcell differentiation
A0031641biological_processregulation of myelination
A0042803molecular_functionprotein homodimerization activity
A0046074biological_processdTMP catabolic process
A0051969biological_processregulation of transmission of nerve impulse
A1905333biological_processregulation of gastric motility
B0000002biological_processmitochondrial genome maintenance
B0001525biological_processangiogenesis
B0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006206biological_processpyrimidine nucleobase metabolic process
B0006213biological_processpyrimidine nucleoside metabolic process
B0006935biological_processchemotaxis
B0007165biological_processsignal transduction
B0008083molecular_functiongrowth factor activity
B0009032molecular_functionthymidine phosphorylase activity
B0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
B0016757molecular_functionglycosyltransferase activity
B0016763molecular_functionpentosyltransferase activity
B0030154biological_processcell differentiation
B0031641biological_processregulation of myelination
B0042803molecular_functionprotein homodimerization activity
B0046074biological_processdTMP catabolic process
B0051969biological_processregulation of transmission of nerve impulse
B1905333biological_processregulation of gastric motility
C0000002biological_processmitochondrial genome maintenance
C0001525biological_processangiogenesis
C0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
C0005515molecular_functionprotein binding
C0005829cellular_componentcytosol
C0006206biological_processpyrimidine nucleobase metabolic process
C0006213biological_processpyrimidine nucleoside metabolic process
C0006935biological_processchemotaxis
C0007165biological_processsignal transduction
C0008083molecular_functiongrowth factor activity
C0009032molecular_functionthymidine phosphorylase activity
C0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
C0016757molecular_functionglycosyltransferase activity
C0016763molecular_functionpentosyltransferase activity
C0030154biological_processcell differentiation
C0031641biological_processregulation of myelination
C0042803molecular_functionprotein homodimerization activity
C0046074biological_processdTMP catabolic process
C0051969biological_processregulation of transmission of nerve impulse
C1905333biological_processregulation of gastric motility
D0000002biological_processmitochondrial genome maintenance
D0001525biological_processangiogenesis
D0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
D0005515molecular_functionprotein binding
D0005829cellular_componentcytosol
D0006206biological_processpyrimidine nucleobase metabolic process
D0006213biological_processpyrimidine nucleoside metabolic process
D0006935biological_processchemotaxis
D0007165biological_processsignal transduction
D0008083molecular_functiongrowth factor activity
D0009032molecular_functionthymidine phosphorylase activity
D0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
D0016757molecular_functionglycosyltransferase activity
D0016763molecular_functionpentosyltransferase activity
D0030154biological_processcell differentiation
D0031641biological_processregulation of myelination
D0042803molecular_functionprotein homodimerization activity
D0046074biological_processdTMP catabolic process
D0051969biological_processregulation of transmission of nerve impulse
D1905333biological_processregulation of gastric motility
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 1481
ChainResidue
BASP304
BHOH2006
BHOH2007

Functional Information from PROSITE/UniProt
site_idPS00647
Number of Residues16
DetailsTHYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE
ChainResidueDetails
ASER144-GLU159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING:
ChainResidueDetails
AHIS116
AARG202
ASER217
ALYS221
BHIS116
BARG202
BSER217
BLYS221
CHIS116
CARG202
CSER217
CLYS221
DHIS116
DARG202
DSER217
DLYS221

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q5FVR2
ChainResidueDetails
ATHR6
BTHR6
CTHR6
DTHR6

221051

PDB entries from 2024-06-12

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