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2WHF

Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0009274cellular_componentpeptidoglycan-based cell wall
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM A 450
ChainResidue
ALEU71
AARG295
ATYR318
ATHR346
APHE347
ASER348
AHIS352
ACYS354
AGLY356
AII41405
AHOH2039
AMET89
AVAL90
AHIS97
AARG101
AMET240
AGLY244
ATHR247
ALEU293

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE II4 A 1405
ChainResidue
ALEU71
AVAL90
AMET91
AGLY243
AVAL290
ALEU293
AHEM450
AII41406

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE II4 A 1406
ChainResidue
APRO88
AASN177
ALEU187
AALA235
APHE238
ATHR239
ATHR242
AII41405

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FShGAHHCLG
ChainResidueDetails
APHE347-GLY356

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AASP93
AHIS97

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:18089574, ECO:0000269|PubMed:19605350
ChainResidueDetails
AARG101
AGLY243
AARG295
ATYR318
ASER348
AHIS352

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS354

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
AASP246
ATHR247

226707

PDB entries from 2024-10-30

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